Dr. Preparation of Metoclopramide-loaded Film Dosage Forms using Natural Polysaccharides
Keywords:Film dosage form; Metoclopramide; Sodium alginate; Pectin; Chitin; Alginic acid.
Natural polysaccharides are used as pharmaceutical or food ingredients. In this study, film dosage forms (FDs) containing the model drug metoclopramide (MCP) were prepared using sodium alginate or pectin as the film base, and the preparations were modified using additives such as chitin. The dissolution profiles of MCP from the FDs in a small volume of physiological saline were investigated. All the forms immediately swelled, disintegrated in physiological saline, and were transformed into a gelatinous substance. When the FD was prepared using sodium alginate, MCP incorporated in the form gradually dissolved into the test solution. In contrast, the drug immediately dissolved if the FD was prepared with pectin. The MCP dissolution rate can be controlled by modification of the film base with suitable additives. These results suggest that FDs prepared using these water-soluble polysaccharides can be useful for administering medicines to persons that have difficulty swallowing.
Yu, Y., et al., Biological activities and pharmaceutical applications of polysaccharide from natural resources: A review. Carbohydrate Polymers, 2018. 183: p. 91-10.
Layek, B. and S. Mandal, Natural polysaccharides for controlled delivery of oral therapeutics: a recent update. Carbohydrate Polymers, 2020. 230: P. 115617.
Guo, X., et al., Structures, properties and application of alginic acid: A review. International Journal of Biological Macromolecules, 2020. 162: p. 618-628.
Raus, R.A., W.M.F.W. Nawawi, and R.R. Nasaruddin, Alginate and alginate composites for biomedical applications. Asian Journal of Pharmaceutical Sciences, 2021. 16(3): p. 280-306.
Ballester, N.M.S., B. Bataille, and I. Soulairol, Sodium alginate and alginic acid as pharmaceutical excipients for tablet formulation: Structure-function relationship. Carbohydrate Polymers, 2021. 270: p. 118399.
Leiman, D.A., et al., Alginate therapy is effective treatment for GERD symptoms: a systematic review and meta-analysis. Diseases of the Esophagus, 2017. 30(5): p. 1-9.
Salvatore, S., et al., The Effect of Alginate in Gastroesophageal Reflux in Infants. Pediatric Drugs, 2018. 20(6): p. 575-583.
Akagi, T., et al., Sodium alginate as an ideal submucosal injection material for endoscopic submucosal resection: preliminary experimental and clinical study. Gastrointestinal Endoscopy, 2011. 74(5): p. 1026-1032.
Espinoza, C.L., et al., Pectin and Pectin-Based Composite Materials: Beyond Food Texture. Molecules, 2018. 23(4): p. 942.
Kumar, M., et al., Delineating the inherent functional descriptors and biofunctionalities of pectic polysaccharides. Carbohydrate Polymers, 2021. 269: p. 118319.
Younes, I. and M. Rinaudo, Chitin and chitosan preparation from marine sources. Structure, properties and applications. Marine Drugs, 2015. 13(3): p. 1133-1174.
Satitsri, S. and C. Muanprasat, Chitin and Chitosan Derivatives as Biomaterial Resources for Biological and Biomedical Applications. Molecules, 2020. 25(24): p. 5961.
Matica, M. A., et al., Chitosan as a Wound Dressing Starting Material: Antimicrobial Properties and Mode of Action. International Journal of Molecular Sciences, 2019. 20(23): p. 5889.
Kravanja, G. et al., Chitosan-based (Nano)materials for Novel Biomedical Applications. Molecules, 2019. 24(10): p. 1960.
Cheng, B., et al., Two kinds of ketoprofen enteric gel beads (CA and CS-SA) using biopolymer alginate. Asian Journal of Pharmaceutical Sciences, 2018. 13(2): p. 120-130.
Piras, C.C., A.K. Patterson, and D.K. Smith, Hybrid Self-Assembled Gel Beads for Tuneable pH-Controlled Rosuvastatin Delivery. Chemistry, 2021. 27(52): p. 13203-13210.
Günter, E.A. and O.V. Popeyko, Calcium pectinate gel beads obtained from callus cultures pectins as promising systems for colon-targeted drug delivery. Carbohydrate Polymers, 2016. 147: 490-499.
Günter, E.A., et al., Preparation and release characteristics of mesalazine loaded calcium pectin-silica gel beads based on callus cultures pectins for colon-targeted drug delivery, International Journal of Biological Macromolecules, 2018. 120(Pt B): p. 2225-2233.
Khan, Q.U.A., et al., Development and characterization of orodispersible film containing cefixime trihydrate. Drug Development and Industrial Pharmacy, 2020. 46(12): p. 2070-2080.
Drumond, N. and S. Stegemann, Better Medicines for Older Patients: Considerations between Patient Characteristics and Solid Oral Dosage Form Designs to Improve Swallowing Experience. Pharmaceutics, 2020. 13(1): p. 32.
Özakar, R.S. and E. Özakar, Current Overview of Oral Thin Films. Turkish Journal of Pharmaceutical Sciences, 2021. 18(1): p. 111-121.
Visser, J.C. et al., Orodispersible films as a personalized dosage form for nursing home residents, an exploratory study. International Journal of Clinical Pharmacy, 2020. 42(2): p. 436-444.
Murata, Y., C. Maida, and K. Kofuji, Drug release profiles and disintegration properties of pectin films. Materials, 2019. 12(3): p. 355-361.
Murata, Y., C. Maida, and K. Kofuji, Disintegration Properties and Drug Release Profiles of Sodium Alginate Films Containing Rebamipide. Research & Development in Material Science, 2021. 15(1): p. 1635-1639.
Saffar, A.A., H. Lennernäs, and P.M. Hellström, Gastroparesis, metoclopramide, and tardive dyskinesia: Risk revisited. Neurogastroenterology & Motility, 2019. 31(11): e13617.
Shakhatreh, M., et al., Metoclopramide for the treatment of diabetic gastroparesis. Expert Review of Gastroenterology and Hepatology, 2019. 13(8): p. 711-721.
Sanogo, S., et al., Validation of RP-HPLC method to assess the compatibility of metoclopramide and midazolam intravenous mixture used in patients with cancer. European Journal of Hospital Pharmacy, 2019. 26(6): p. 323-328.
How to Cite
Copyright (c) 2022 Yoshifumi Murata
This work is licensed under a Creative Commons Attribution 4.0 International License.