Synthesis and Antibacterial Activity of 6-bromo-2-(o-aminophenyl)-3-amino-Quinazolin-4(3H)-one from 6-bromo,2-(o-aminophenyl)-3,1-benzoxazin-4(3H)-one.


  • Osarumwense Peter Osarodion Department of Chemical Science, Ondo State University of Science and Technology, Okitipupa, Ondo State, Nigeria



Antibacterial activity, Quinazolinone derivatives, 6-bromo-2-(o-aminophenyl)-3-amino-Quinazolin-4(3H)-one, 6-bromo,2-(o-aminophenyl)-3,1-benzoxazin-4(3H)-one


Introduction: Quinazolinone derivatives reveal various medicinal properties such as analgesic, anti-inflammatory and anticancer activities, as well as antimicrobial activity. These heterocycles are valuable intermediates in organic synthesis. Methods/Experimental: The compound, 6-bromo,2-(o-aminophenyl)-3,1-benzoxazin-4(3H)-one (1) was synthesized by dissolving 5-bromo anthranillic acid in 100 ml of pyridine. To this reaction mixture o-amino benzoyl chloride stirring at room temperature for 30 minutes this was refluxed with 75 mL of hydrazine hydrate for 3 hrs. at 120-1300C. the reaction mixture was allowed to cool to room temperature to give 6-bromo-2-(o-aminophenyl)-3-amino-Quinazolin-4(3H)-one (2). These Compounds were evaluated for their bacterialrial activity (against some gram positive and gram-negative microorganism) and antifungal activity (against Candida albicans). Study Design: This study was experimentally design and the antibacterial activity was evaluated against some microorganism, Staphylococcus aureus, Bacillus species, Aspergillus Species, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumonia, and candida albicans. Result: The compounds exhibited significant antibacterial activity with a zone of inhibition in the range of 10 – 16mm in comparison to control.  Conclusions: From our findings, the compounds synthesized have higher antibacterial activities as compared to Ciprofloxicin (CPX) and Ketonaxol (PEF) standard antibacterial drugs.




How to Cite

Osarodion, O. P. (2023). Synthesis and Antibacterial Activity of 6-bromo-2-(o-aminophenyl)-3-amino-Quinazolin-4(3H)-one from 6-bromo,2-(o-aminophenyl)-3,1-benzoxazin-4(3H)-one . European Journal of Applied Sciences, 11(3), 11–20.