Psychological and Physiological Profiles in Oncology Caregivers: A Multivariable Cross-Sectional Study

  • Esther García CIBER-BBN, Barcelona, Spain
  • Sira Aguiló Hospital Clínic, Barcelona, Spain
  • Adriana Arza CIBER-BBN, Barcelona, Spain Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Jorge M. Garzón-Rey CIBER-BBN, Barcelona, Spain Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Jordi Aguilóa CIBER-BBN, Barcelona, Spain Universitat Autònoma de Barcelona, Barcelona, Spain.
Keywords: Oncology caregivers, Stress biomarkers, Chronic stress, Psicometric tests

Abstract

Scientific research has led to enhanced medical assistance, and hence higher disease control and a continuous lifespan dilation. However, research mainly focusses on the patient’s condition, and, in some cases, caregivers’ health is undervalued. In this paper, a close-related emotionally involved caregiver group is examined and compared to a non-caregiver group in order to investigate the role of chronic stress in their psychological and physiological state. For this purpose, blood, saliva, and hair samples, physiological signals and three validated psychometric tests are collected from both groups. Results from 39 subjects show interesting significant differences among all the psychometric profiles between the two groups although no sufficient biochemical data supports the relation with potential health consequences.    

 

References

(1) Schulz R, Sherwood PR. Physical and mental health effects of family caregiving. Am J Nurs. 2008;108(9 Suppl):23-7; quiz 27. doi: 10.1097/01.NAJ.0000336406.45248.4c.

(2) Vitaliano PP, Zhang J, Scanlan JM. Is caregiving hazardous to one's physical health? A meta-analysis. Psychol Bull. 2003;129:946-72.

(3) Pinquart M, Sörensen S. Associations of stressors and uplifts of caregiving with caregiver burden and depressive mood: a meta-analysis. J Gerontol B Psychol Sci Soc Sci. 2003;58:P112-28.

(4) Oliva-Moreno J, Trapero-Bertran M, Peña-Longobardo LM, Del Pozo-Rubio R. The Valuation of Informal Care in Cost-of-Illness Studies: A Systematic Review. Pharmacoeconomics. 2017;35:331-345.

(5) Stenberg U, Ruland CM, Miaskowski C. Review of the literature on the effects of caring for a patient with cancer. Psychooncology. 2010;19:1013-25.

(6) Carmeli E. The invisibles: unpaid caregivers of the elderly. Front Public Health. 2014;2:91. doi: 10.3389/fpubh.2014.00091.

(7) Rosengren A, Hawken S, Ounpuu S, Sliwa K, Zubaid M, Almahmeed WA, et al. Association of psychosocial risk factors with risk of acute myocardial infarction in 11119 cases and 13648 controls from 52 countries (the INTERHEART study): case-control study. Lancet. 2004;364:953-62.

(8) von Känel R, Mausbach BT, Dimsdale JE, Mills PJ, Patterson TL, Ancoli-Israel S, et al. Cardiometabolic effects in caregivers of nursing home placement and death of their spouse with Alzheimer's disease. J Am Geriatr Soc. 2011;59:2037-44.

(9) Roepke SK, Allison M, Von Känel R, Mausbach BT, Chattillion EA, Harmell AL, et al. Relationship between chronic stress and carotid intima-media thickness (IMT) in elderly Alzheimer's disease caregivers. Stress. 2012;15:121-9.

(10) Siddiqui A, Madhu SV, Sharma SB, Desai NG. Endocrine stress responses and risk of type 2 diabetes mellitus. Stress. 2015;18:498-506.

(11) Selye H. Stress and the general adaptation syndrome. Br Med J. 1950; 1: 1383-92.

(12) Choi J, Ahmed B, Gutiérrez-Osuna R. Development and evaluation of an ambulatory stress monitor based on wearable sensors. IEEE Trans Inf Technol Biomed 2012; 16: 279-86.

(13) Thayer JF, Åhs F, Fredrikson M, Sollers JJ, Wager TD. A metaanalysis of heart rate variability and neuroimaging studies: implications for heart rate variability as a marker of stress and health. Neurosci Biobehav Rev 2012; 36: 747-56.

(14) Visnovcova Z, Mestanik M, Javorka M, Mokra D, Gala M, Jurko A, et al. Complexity and time asymmetry of heart rate variability are altered in acute mental stress. Physiol Meas 2014;

: 1319-34.

(15) Vlemincx E, Taelman J, De Peuter S, Van Diest I, Van den Bergh O. Sigh rate and respiratory variability during mental load and sustained attention. Psychophysiology 2011; 48: 117-20.

(16) Allen AP, Kennedy PJ, Cryan JF, Dinan TG, Clarke G. Biological and psychological markers of stress in humans: focus on the Trier Social Stress Test. Neurosci Biobehav Rev 2014; 38: 94-124.

(17) De Santos-Sierra A, Ávila CS, Casanova JG, Del Pozo GB. Real-time stress detection by means of physiological signals. Recent Application in Biometrics 2011; 58: 4857-65.

(18) Haufe S, Kim JW, Kim IH, Sonnleitner A, Schrauf M, Curio G, et al. Electrophysiology-based detection of emergency braking intention in real-world driving. J Neural Eng 2014; 11: 056011.

(19) Vinkers CH, Penning R, Hellhammer J, Verster JC, Klaessens JH, Olivier B, et al. The effect of stress on core and peripheral body temperature in humans. Stress 2013; 16:

-30.

(20) Schulz, P., Kirschbaum, C., Prüßner, J. and Hellhammer, D. Increased free cortisol secretion after awakening in chronically stressed individuals due to work overload. Stress Med.1998;14:91–97.

(21) Hjortskov, N., Garde, A. H., Ørbæk, P. and Hansen, Å. M. Evaluation of salivary cortisol as a biomarker of self-reported mental stress in field studies. Stress and Health, 2004;20: 91–98. doi:10.1002/smi.1000

(22) Russell E1, Koren G, Rieder M, Van Uum S. Hair cortisol as a biological marker of chronic stress: current status, future directions and unanswered questions. Psychoneuroendocrinology. 2012; 37(5):589-601.

(23) Yalta K, Yalta T, Sivri N, Yetkin E. Copeptin and cardiovascular disease: a review of a novel neurohormone. Int J Cardiol 2013; 167: 1750-9.

(24) Urwyler SA, Schuetz P, Sailer C, Christ-Crain M. Copeptin as a stress marker prior and after a written examination–the CoEXAM study. Stress 2015; 18: 134-7.

(25) Chrousos GP, Gold PW. The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. JAMA. 1992; 267(9):1244-52.

(26) Cohen S, Kamarck T, Mermelstein R. A global measure of perceived stress. J Health Soc Behav 1983; 24: 385-96.

(27) Monk TH. A visual analogue scale technique to measure global vigor and aff ect. Psychiatry Res 1989; 27: 89-99.

(28) Spielberger CD, Gorsuch RL, Lushene R, Vagg PR, Jacobs

GA. Manual for the State-Trait Anxiety Inventory. Palo Alto, CA: Consulting Psychologists Press; 1983.

(29) Whalen KJ, Buchholz SW. The reliability, validity and feasibility of tools used to screen for caregiver burden: a systematic review. JBI Libr Syst Rev. 2009;7:1373-1430.

(30) Aguiló J, Ferrer-Salvans P, García-Rozo A, Armario A, Corbí Á, Cambra FJ, et al. Project ES3: attempting to quantify and measure the level of stress. Rev Neurol. 2015;61:405-15.

(31) Scorrano F, Carrasco J, Pastor-Ciurana J, Belda X, Rami-Bastante A, Bacci ML, et al. Validation of the long-term assessment fhypothalamic-pituitary-adrenal activity in rats using hair orticosterone as a biomarker. FASEB J. 2015;29:859-67.

Published
2017-09-01
Section
Special Issue : 1st International Conference on Affective computing, Machine Learning and Intelligent Systems