Role of trace elements In duchenne muscular dystrophy
Keywords:Duchenne muscular dystrophy, Trace elements, Flame atomic absorption, Multiple and partial correlation coefficiments and regression equations
Atomic absorption analysis involves measuring the absorption of light by vaporized ground state atoms and relating the absorption to concentration. The incident beam of light is attenuated by atomic vapour absorption according to Beer’s Law. The estimation of trace elements show a colorful presentation of different metals . It has been seen and found that the levels of zinc and selenium were lower in DMD cases in comparison to healthy controls. The elements such as copper, calcium, iron, magnesium, potassium, sodium were found higher than controls.On the basis of statistical analysis we have measured regression and correlation coefficients including Multiple correlation coefficients between different trace elements like Na, K, Ca, Mg, Zn, Cu, Fe and Selenium in normal samples.A trend has been found in coefficient of correlation such as > > > with positive correlation and > > > with negative correlation.Coefficient of partial correlation is also calculated and found that a trend has been set up between trace elements and given here as > > > > > > with positive correlation and we have found also a negative correlation between some of the elements and a trend is given here as > >
Multiple correlation coefficient in normal healthy person has been estimated and found that a trend , which is given here as > > > > > > > > >.
We have also measured correlation coefficients including multiple correlation coefficients between different types of trace elements like Na, K, Ca, Mg, Zn, Cu, Fe and Selenium in DMD samples. A trend has been found in coefficient of correlation such as > > > with positive correlation
and > > > with negative correlation. Coefficient of partial correlation is also calculated and found that a trend has been set up between trace elements and given here as > > with negative correlation and also found a trend of positive correlation as > > > > > .
Multiple correlation coefficient in DMD patients has been estimated and found that a trend , which is given here as > > > > > > > > > .
Our findings suggest that the values of higher levels of trace elements should be adjusted such that these levels must slight below or equal to the normal limits of the particular element. The levels of zinc and selenium should be maintained within the normal limits for DMD cases in comparison to healthy controls. The elements such as copper, calcium, iron, magnesium, potassium, sodium may be reduced up to the normal limits in comparison to healthy persons
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