Role of trace elements In duchenne muscular dystrophy
DOI:
https://doi.org/10.14738/jbemi.15.480Keywords:
Duchenne muscular dystrophy, Trace elements, Flame atomic absorption, Multiple and partial correlation coefficiments and regression equationsAbstract
Atomic absorption analysis involves measuring the absorption of light by vaporized ground state atoms and relating the absorption to concentration. The incident beam of light is attenuated by atomic vapour absorption according to Beer’s Law. The estimation of trace elements show a colorful presentation of different metals . It has been seen and found that the levels of zinc and selenium were lower in DMD cases in comparison to healthy controls. The elements such as copper, calcium, iron, magnesium, potassium, sodium were found higher than controls.On the basis of statistical analysis we have measured regression and correlation coefficients including Multiple correlation coefficients between different trace elements like Na, K, Ca, Mg, Zn, Cu, Fe and Selenium in normal samples.A trend has been found in coefficient of correlation such as > > > with positive correlation and > > > with negative correlation.Coefficient of partial correlation is also calculated and found that a trend has been set up between trace elements and given here as > > > > > > with positive correlation and we have found also a negative correlation between some of the elements and a trend is given here as > >
Multiple correlation coefficient in normal healthy person has been estimated and found that a trend , which is given here as > > > > > > > > >.
We have also measured correlation coefficients including multiple correlation coefficients between different types of trace elements like Na, K, Ca, Mg, Zn, Cu, Fe and Selenium in DMD samples. A trend has been found in coefficient of correlation such as > > > with positive correlation
and > > > with negative correlation. Coefficient of partial correlation is also calculated and found that a trend has been set up between trace elements and given here as > > with negative correlation and also found a trend of positive correlation as > > > > > .
Multiple correlation coefficient in DMD patients has been estimated and found that a trend , which is given here as > > > > > > > > > .
Our findings suggest that the values of higher levels of trace elements should be adjusted such that these levels must slight below or equal to the normal limits of the particular element. The levels of zinc and selenium should be maintained within the normal limits for DMD cases in comparison to healthy controls. The elements such as copper, calcium, iron, magnesium, potassium, sodium may be reduced up to the normal limits in comparison to healthy persons
References
Petrof, B., Shrager, J., Stedman, H., Kelley, A. and Sweeney, H. (1993) : Dystrophin protects the sarcolemma from stresses developed during muscle contraction. Medical. Sciences, 90, Retrived from http:// www. pnas. org/content/90/8/3710.full.pdf.
Emery, A. E. (2002) : The muscular dystrophies. Lancet, 359 (9307), 687.
Bach, R. J. (1999 ) : Introduction In : Guide to the evaluation and management of neuro muscular disease. Hanley & Belfus. Inc. Philadelphia P. A. , pp. 1-4.
Meryon, E. (1852) : On grannular and fatty degeneration of the voluntary muscles, Med. Chir. Trans. 35, 72- 84
Duchenne, G. B. A. (1868) : Researches Sur la paralysic musculaire pseudo hypertrophic or paralysie myo-sclero sique, Arch. Gen. Med., 11, 5- 25.
Maser, H. (1984) : Duchenne muscular dystrophy : Pathogenetic aspects and genetic prevention. Hum. Genet., 66, 17-40.
Emery, A. E. (1991): Population frequencies of inherited neuromuscular disease – a world survey. Neuromuscular. Disord. 1(1), 19-29.
Abood, E. A., Jones, M. M. (1991) : Macrophages in developing mammalian skeletal muscle : evidence for muscle fibre death as a normal developmental event. Acta. Anat (Basel) 140 (3), 201-212.
Simonds, A. K., Muntani, F., Heather, S., Fielding, S. (1998) : Impact of nasal ventilation on survival in hypercapnic Duchenne muscular dystrophy, Therax, 53 (11), 949-952.
Somer, H., Donner, M., Murros, J., Konttinen, A. (1973) : A serum isoenzyme study in muscular dystrophy. Particular reference to creatine kinase, aspartate aminotransferase, and lactic acid dehydrogenase isozymes. Arct. Meyral, 29 (5), 343-345.
Mokri, B., Engel, A. G. (1975) : Duchenne dystrophy : electron microscopic findings pointing to a basic or early abnormality in the plasma membrane of muscle fibre. Neurology, 25 (12), 111-1120.
Engel, J., Furthmayr, H. Odermatt, E., Vender Mark, H., Aumailley, M., Fleischmajer, R., and Timpl, R. (1985) : Structure and macromolecular organization of type VI Collagen, Ann. N. Y. Acad. Sci., 460, 25-37.
Gillis, J. M. (1999) : Understanding dystrophinopathies : an inventory of the structural and functional consequences of the absence of dystrophin in muscles of the mdx mouse. J. Muscle. Res. Cell. Motil, 20 (7), 605-625.
Sandri, M., Minetti, C., Pedemonte, M., Carraro, U. (1998) : Apoptotic myonuclei in human Duchenne muscular dystrophy. Lab. Invest., 78 (8), 1005-1016.
Tidball, J. G., Albrecht, D. E., Lokensgal, B. E., Spencer, M. J. (1995): Apptasis precedes necrosis of dystrophin deficient muscle, J. Cell. Sci., 108 (6), 2197-2204.
Matsuda, R., Nishikawa, A., Tanaka, H. (1995) : Visualization of dystrophic muscle fibers in mdx mouse by vital staining with Evans blue : evidence of apoptosis in dystrophin-deficient mouscle. J. Biochem (Tokye), 118 (5), 959-964.
Spencer, M. J., Walsh, C. M., Darsh kind, K. A., Rodriguez, E. M. and Tidball, J. G. (1997) : Myonuclear apoptosis in dystrophic mdx muscles occurs by perforin-mediated cytotoxicity. J. Clin. Invest., 99 (11), 2745-2751.
Bradley, W. G., Hudgson, P., Larson, P. F., Papapetropoulas, T. A. and Jenkison, M. (1972) : Structural changes in the early stages of Duchenne muscular dystrophy. J. Neurol. Neuro Surg. Psychiatry., 35 (4), 451-455.
Bowman, W. (1840) : On the minute structure and movements of voluntary muscle. Philos. Trans. R Soc. London. Biol., 130, 457- 501.
Murphy, D. L., Mendell, J. R. and Engel, W. K. (1973) : Serotonin and platelet function in Duchenne’s muscular dystrophy. Arch. Neurol. 28, 239-242.
Paulsan, O. F., Engel, A. G. and Gomez, M. R. (1974) : Muscle blood flow in Duchenne type muscular dystrophy, limb-gridle dystrophy, polymyositis and in normal controls, J. Neurol. Neuroserg. Psychioatry, 37, 685-690.
Jerusalem, F., Engel, A. G. and Gomez, M. R. (1974) : Duchenne dystrophy. I. Morphometric study of the muscle micro vascular. Brain, 97, 115-122.
Mc Comas, A. J., Sica, R. E. P. and Currie, S. (1971) : An electrophysiological study of Duchenne dystrophy. J. Neurol. Neurosurg. Psychiatry, 34, 461-468.
Panayiotopoulos, C. P., Scarpalezos, S. and Papapetropoulos, T. (1974) : Electrophysiological estimation of motor units in Duchenne muscular dystrophy. J. Neurol. Sci., 23, 89-98.
Ballantyne, J. P. and Hansen, S. (1974) : New method for estimation of the number of motor units in a muscle. 2. Duchenne, limb-girdle and facioscapulohumerol, and myotonic muscular dystrophies. J. Neurol. Neurosurg. Psychiatry, 37, 1195-1201.
Matheson, D. M. and Howland, J. L. (1974) : Erythrocyte deformation in human muscular dystrophy. Science, 184, 165-166.
Miale, T. D., Frias, J. L. and Lawson, D. L. (1975) : Erythrocytes in human muscular dystrophy, Science 187, 453.
Miller, S. E., Roses, A. D. and Appel, S. H. (1975) : Erythrocytes in human muscular dystrophy, Science, 188, 1131.
Brown, H. D., Chattpadyay, S. K. and Patel, A. B. (1967) : Erythrocyte abnormality in human myopathy, Science, 157, 1577-1578.
Peter, J. B. Worsfold, M. and Pearson, C. M. (1969) : Erythrocyte ghost adenosine triphosphate (AT Pase) in Duchenne dystrophy. J. Lab. Clin. Med., 74, 103-108.
Roses, A. D., Herbstreith, M. H. and Appel, S. H. (1975) : Membrane protein kinease alteration in Duchenne muscular dystrophy. Nature, 254, 350-351.
Mawatari, S., Takagi, A. and Rowland, L. P. (1974) : Adenyl cyclase in normal and pathologic human muscle, Arch Neurol. 30, 96-102.
Pearce, G. W., Pearce, J. M. S. and Walton, J. N. (1966) : The Duchenne type muscular dystrophy : Histopathological studies of the carrier state, Brain, 89, 109-120.
Roy, S. and Dubowitz, V. (1970) : Carrier detection in Duchenne muscular dystrophy, J. Neurol. Sci., 11, 65-79.
Ionasescu, V., Zellweger, H. and Conway,T. W. (1971) : Ribosomal protein synthesis in Ducheme muscular dystrophy, Arch. Bio Chem. Biophys., 144, 51-58.
Ionasescu, V., Zellweger, H. Shirk, P. and Conway, T. W. (1973) : Identification of carriers of Duchenne muscular dystrophy by muscle protein synthesis. Neurology, 23, 497-501.
Roses, A. D., Roses, M. J., Miller, S. E., Hull, K. L. and Appel, S. M. (1976) : Carrier detection in Duchenne muscular dystrophy. New. Engl. J. Med., 294, 193-197.
Hobbins, J. C. and Mahoney, M. J. (1974) : In utero diagnosis of hemoglobinopathies. Technique for obtaining fetal blood. New. Engl. J. Med., 290, 1065-1067.
Bodensteiner, J. B. and Engel, A. G. (1978) : Intracellular calcium accumulation in Duchenne dystrophy and other myopathies. A study of 56, 7,000 muscle fibers in 114 biopsies. Neurology, 28, 439-446.
Bertorini, T. E., Bhattacharya, S. K., Polmieri, G. M. A., Chesney, C. M., Bifer, D. and Baker, B. (1982) : Muscle calcium and magnesium content in Duchenne muscular dystrophy. Neurology, 32, 1088-1092.
Schotland, D. L., Bonilla, E. and Wakayama, Y. (1980) : Application of the freeze fraeture technique to the study of human neuromuscular diseases, Muscle. Nerve., 3, 21-27.
Schotland, D. L., Bonilla, E. and Van Meter, M. (1977) : Duchenne dystrophy alteration in plasma membrane structure, Science, 196, 1005-1007.
Peluchretti, D., Mora, M., Protti, A. and Cornelio, F. (1985) : Freeze fracture analysis of the muscle fiber plasma membrane in Duchenne dystrophy, Neurology, 35, 928-930.
Heimann-Patterson, T. D., Bonilla, E., and Schotland, D. L. (1982) : Cancanavalin A binding of the Cell surfac of Duchenne muscle in vitro. Ann. Neurol., 12, 305-307.
Brooke, M. H. (1986) : Muscular dystrophies, In : A clinician’s view of neuromuscular disease. Edited by Nancy, McSherry, C. and Victoria, M. V., Williams & Wilkins, Baltimore, London Los Angles Sytdney. PP. 117-154.
Ionasescu, V., Ionaseesu, R., Feld, R., Write, D., Cancilla, P., Kaeding, L. and Stern, L. Z. (1991 : Alterations in creatine kinase in fresh muscle and cell cultures in Duchenne dystrophy. Ann. Neurol., 9, 394-399.
Thompson, E. J., Yasin, R., Vanbeer S. G., Nurse, K. and Al-Ani, S. (1977) : Myogenic defect in human muscular dystrophy, Nature, 268, 241-243.
Rothman, S. M. and Bischoff, R. (1983) : Electrophysiology of Duchenne dystrophy myotubes in tissue culture. Ann. Neurol., 13, 176-179.
Mawatari, S., Miranda, A., and Rowland, L. P. (1976) : Adenyl Cyelase abnormality in Duchenne muscular dystrophy : muscle cells in culture, Neurology, 26, 1021-1026.
Cerri, C. A., Willner, J. H., and Miranda, A. F. (1982) : Adenylate cyclase in Duchenne fibroblasts. J. Neurol. Sci., 53, 181-185.
Rowland, L. P. (1980) : Biochemistry of muscle membranes in Duchenne dystrophy, Muscle. Nerve., 3, 3-20.
Falk, R. S., Campion, D., Guthrie, B., Sparkes, R. S. and
Fox, C. F. (1979) : Phospharylation of the red cell membrane proteins in Duchenne muscular dystrophy. New. Engl. J. Med., 300, 258-259.
Fischer, S., Tortolero, M., Piau, J. P., Pelaunay, J. and Schapira, G. (1978) : Protein kinase and adanylate kinase of erythrocyte membrane from patients with Duchenne dystrophy. Clin. Chem. Acta., 88, 437-440.
Roses, A. D., Mabry, M. E., Herbstreith, M. H., Shile, E. V. and Balakrishnan, O. V. (1982) : Increased phospharylation of spectrin peptides in Duchenne muscular dystrophy. In : Disorders of the Motor Unit Edited by Schotland, D. L., John Wiley & Sons, New York, PP. 413-420.
Mabry, M. E. and Roses, A. D. (1981) : Increased 32P-phashorylase of triptic peptides of erythrocytes spectrin in Duchenne muscular dystrophy Muscle Nerve, 4, 489-493.
Roses, A. D., Shile, P. E., Herbstreith, M. H. and Balakrishnan, C. V. (1981) : Identification of abnormality 32P-phashorylated cyanogen bromide cleavage product of erythrocyte membrane spectrin in Duchenne muscular dystrophy, Neurology, 31, 1026-1030.
Arthur, H., De Niese, M., Jeffrey, P. L. and Austin, L. (1983) : Plasma lipoprotein in Duchenne muscular dystrophy, Biochem. Int. 6, 307-313.
Personalhealthfacts. com (1985) : The importance of trace minerals, NFM’S, Nutrition Science, News , pp. 1-4.
Romeyn, M. (1998) : Vitamins, Minerals and Trace elements. In :Nutrition and HIV. Edited by Jossey-Bass Inc. Sonsome Street San Francisco.
Herring, W. B., Leavell, B. S., Paixao, L. M. and Yoe, J. H., (1960) : Trace metals in human plasma and red blood cells, American Journal of Clinical nutrition, Vol. 8, pp. 846-854.
Khurshid, S. J. and Qureshi, I. H. (1984) : The role of inorganic elements in human body, The Nucleus, Vol. 21, pp. 3-23.
Suhaila, R., Nasir, K., Shujaat, A., Nasim, U. and Mohammad, Z .I. (2004) : Essential trace metals in human whole blood in relation to environment, Pakistan J. Med. Res., Vol. 43, No. 2, pp. 1-5.
Kumar, S. (1989) : Medico-Physical studies on epilepsy and other neurological disorders, Ph.D. Thesis, University of Delhi, India.
Mary, R. L. A., Kelvin, A. C., Sheila, D. and William, H. R. (2000) : Nutrient risk assessment implication for food fortification policy, In : Trace elements in man and animals, 10. Edited by Rousel, A. M., Anderson, R. A., Favrier, A., Kluwer Academic Publications, N. Y., Boston, Dodrecht, Lands, Moscow. pp 215 - 220
Alexander, G. S. (1995) : Minerals and Human health : The rationale for optimal and balanced trace element levels, Tacoma, Life. Sciences. Press. pp 1-5.
Pike, R. L. and Brown, M. L. (1984) : An Integrated Approach .In : Nutrition., John Wiley & Sons, pp. 197.
Zumkley, H. (1987) : Trace elements in medicine, Fresenius Z., Anal Chem, Vol. 327, No. 1, pp. 6.
Davies, I. J. J. (1972) : Clinical significance of the essential biological metals, In: Animal health and hygiene (general), William Heineman, London, pp. 48– 26. I.S.B.N. 0433071702 .
Burns, R. R. and Fell, G. S. (1976) : Estimation and interpretation of plasma zinc fractions, Secott. Med. J., Vol. 21, pp. 153-154.
Prasad, A. S., and Oberleas, D. (1970) : Binding of zinc to amino acids and serum proteins in vitro, J. Lab. Clin .Med., Vol. 76, No. 3, pp. 416-425.
Kelin, D. and Mann, J. (1940) : Carbonic anhydrase : Purification and nature of the enzyme, Biochem J, Vol. 34, No. 8&9, pp. 1163-1176.
Riordan, J. F. and Vallee, B. L. (1976) : Structure and function of zinc metalloenzymes,In Trace Elements in human health and disease. Edited by Prasad, A. S. Vol. 1. Academic Press, New York, pp. 227-251.
Chavapil, M., Zukowski, C. F., Hattler, B. G., Stankova, L., Montgomery, D., Carlson, E. C. and Ludwig, J. C. (1976) : Zinc and activity of cell membrane. In : Trace-elements in human health and disease . Edited by Prasad, A. S. Vol. 1, Academic Press, New York, pp. 269-281.
Prasad, A. S., Schulert, A. R., Sandstead, H. H., Miale. A.
Jr., and Farid, Z., (1963): Zinc, iron and nitrogen content of sweat in normal and deficient subjects, J. Lab. Clin .Med., Vol.
, pp. 84-89.
Walravens, P. A., Doornick, W. J. V. and Hambidge, K. M. (1978) : Metals and Mental Function, J. Ped., Vol. 93, No. 3, pp .535.
Henkin, R. I., Patten, B. M., Re, PK., Bronzett, D. A., (1975) : A syndrome of acute zinc loss, Arch Neurol, Vol. 32, No. 11, pp. 745-751.
Dresti, I. E. (1984) : Zinc in the central nervous system : The emerging interactions. In : The Neurobiology of Zinc Part A. Edited by Frederickson, C. J., Howell, G. A. and Kasarskis, E. J., Alan R. L., New York, pp. 1-26.
Fairbanks, V. F., Fahey, J. L. and Beutler, E. (1971) : Clinical disorders of Iron metabolism, 2nd ed., Grune and Stratton, New York, pp. 1-486.
Mc Cance and Widdowson, E. M. (1937) : Absorption and excretion of iron, Lancet, Vol. 2, pp. 680-684.
Gramick, S. (1946) : Ferritin IX. Increase of the protein apoferritin in the gastrointestinal mucosa as a direct response to iron feeding. The function of ferritin in the regulation of iron absorption, J. Biol. Chem. Vol. 164, pp. 737-746.
Moore, C. V., Doan, C. A. and Arrowsmith, W. R. (1937) : Studies in iron transportation and metabolism, mechanism of iron transportations : Its significance in iron utilization in anemic states of varied etiology. J. Clin. Invest., Vol. 16, No. 4, pp. 627-648.
Mahler, H. R. and Elowe, D. G. (1953) : DPNH cytochrome reductase, a ferroflavo protein, J. Amer. Chem. Soc., Vol. 75, pp. 5769-5770.
Richert, D. A. and Westerfeld, W. W.(1954) : The relationship of iron to xanthime oxidase, J. Biol. Chem., Vol. 209, pp. 179-189.
Fisher, H. and Zeile, K. (1929) : Synthesis of hematoprophyrin, protoporphyrin and hemin, Ann. European Journal of Organic Chemistry, Vol. 468 , No. 1, pp. 98-116.
Ingram, D. J. E., Gibson, J. F. and Perutz, M. F. (1956) : Orientation of the four heme groups in hemoglobin, Nature, Vol. 178, pp. 906-908.
Holmberg, G. C. and Laurell, C. B. (1947) : Investigations in serum copper I. Nature of serum copper and its relation to the iron-binding protein in human serum. Acta Chem. Scand. Vol. I, pp. 944-950.
Schade, A. L., Reinhart, R. W., and Levy, H., (1949) : Carbon dioxide and oxygen in complex formation with iron and siderophilin, the iron-binding compound of human plasma, Arch Biochem., Vol. 20, No. 1, pp. 170-172.
Lipschitz, D. A., Cook, J. D. and finch, C. A., (1974) : A clinical evaluation of serum ferritin as an index of iron stores. New. Eng. J. Med., Vol. 290, pp. 1213-1216.
Simes, M. A., Addiego, J. E., Jr., and Dallman, P. R., (1974) : Ferritin in serum : Diagnosis of iron deficiendcy and iron overload in infants and children, Blood, Vol. 43, No. 4, pp. 581-590.
Aikawa, J. K. (1971) : The relationship of magnesium to diseases in domestic animals and in human, Charles C. Thomas. Springfield, Illinois, pp. 1-145.
Aikawa, J. K. (1976) : Biochemistry and physiology of magnesium. In: Trace Elements in Humans : Health and diseases, Vol. II, Edited by Prasad, A. S., .Academic Press, New York, pp. 47-78.
Widdowson, E. M., McCance, R. A. and Spray, C. N. (1951) : The clinical composition of the human body, Clin. Sci., Vol. 10, pp. 113-125.
Waterlow J.C. ( 1992) : Endocrine changes in severe PEM .In: Protein-Energy Malnutrition, Edited by Waterlow, J. C., London, Edward Arnold , pp. 112-125.
Classen, H. G., (1984) : Magnesium and potassium deprivation and supplementation in animals and man : aspects in view of intestinal absorption. Magnesium, Vol. 3, No. 4-6, pp. 257-264.
Al-Ghamdi, S. M., Cameron, E. C., and Sutten, R. A., (1994) : Magnesium deficiency : Pathophysiologic and Clinical Overview, Am. J. Kidney. Dis., Vol. 24, No. 5, pp. 737-752.
Wester, P. (1987) : Magnesium, Am. J. Clin. Nutr., Vol. 45, Supplement, pp. 1305-1312.
Krasner, B. (1979) : Cardiac effects of magnesium with special reference to anaesthesia : a rewiew, Can Anaesth Soc J., Vol. 26 No. 3, pp. 181-185.
Furukawa, Y., and Chiba, S., (1981) : Effects of magnesium on the isolated, blood-perfused atrial and ventricular preparations of the dog heart, Jpn. Heart. J.,Vol . 22, No. 2, pp. 239-246.
Stark, G., Stark, U., Pilger, E., Honigl, K., Bertuch, H. and Tritthart, H. A., (1989): The influence of elevated Mg2+ concentrations on cardiac electrophysiological parameters, Cardiovasc. Drugs. Ther., Vol. 3, No. 2, pp. 183-189.
Haigney, M.C.P., Berger, R., Schulman, S., Gerstenblith, G. ,Tunin. C Silver, B., Silverman, H. S., Tomaselli, G and Calkins, H (1997) : Tissue magnesium levels and the arrhythmic substrate in humans, J Cardiovasc Electrophysiol.,Vol. 8, No. 9, pp. 980-986.
Ireland, P., and Fordtran, J. S., (1973) : Effect of dietary calcium and age on jejunal calcium absorption in humans studied by intestinal perfusion, J. Clin. Investig., Vol. 52, No. 11, pp. 2672-2681.
Heaney, R. P., Saville, P. D., and Recker, R. R., (1975) : Calcium absorption as a function of calcium intake, J .Lab. Clin Med.,Vol. 85, No. 6, 881-890.
Wilkinson, R. (1976) : Absorption of calcium, phosphorus and magnesium calcium phosphate and magnesium metabolism. Edited by Nordin, B. E. C., Edinberg, Churchill Livingstone, pp. 36-112.
Marshall, D. H. (1976) : Calcium and phosphate kinetics calcium, phosphate and magnesium metabolism. Edited by Nordin, B. E. C. Edinberg, Churchill Livingstone, pp. 257-297.
Morris, H. A., Need, A. G., Horowitz, M., O’Loughlin, P. D., and Nordin, B. E., (1991): Calcium absorption in normal and osteoporotic postmenopausal women, Calcif. Tissue. Int., Vol. 49, No. 4, pp. 240-243.
Ebeling, P. R., Yergey, A. L. and Vleira, N.E. (1994) : Influence of age on effects of endogeneous 1, 25-dihydroxyvitamin D on calcium absorption in normal women, Calcif .Tissue. Int., Vol. 55 , No. 5 , pp. 330-334.
Need, A. G., Morris, H. A., Horowitz, M., Scopacasa, E. and Nordin, B. E., (1998): Nordin. Intestinal calcium absorption in men with spinal osteoporosis, Clin. Endocrinol., Vol. 48 , No. 2, pp. 163-168.
Nordin, B. E. C. (1976) : Nutritional considerations in : Calcium, phosphate and magnesium metabolism. Edited by Nordin, B. E. C., Edinberg, Churchill Livingstone, pp. 1-35.
Kent, G. N., Price, R. I., and Gutteridge, D. H., Allen, J. R., Barnes, M.P., Hickling, Retallack, R. W., Wilson, S.G., Delvin, R.D., Price, R.I., Simith, M., Bhagat, C.I., Davies, C, St. Johns, A., (1990) : Human lactation : forearm trabecular bone loss, increased bone turnover, and renal conservation of calcium and inorganic phosphate with recovery of bone mass following weaning, J. Bone. Miner. Res.,Vol. 5, No. 4, pp. 361-369.
Lopez, J. M., Gonzalez, G., Reyes, V., Campino, C. and Diaz, S. (1996): Bone turnover and density in healthy women during breastfeeding and after weaning, Osteoporos. Int., Vol. 6, No. 2, pp. 153-159.
Chan, G. M., McMurray, M., Westover, K., Engelbert-Fenton, K., and Thomas, M. R., (1987): Effects of increased dietary calcium intake upon the calcium and bone mineral status of lacting adolescent and adult women, Am. J. Clin. Nutr., Vol . 46, No. 2, pp. 319-323.
Katz, M., and Steihm, E.R. (1977): Host defense in malnutrition. Pediatr. Vol. 59, No. 4, pp. 490-495.
Suskind, R.M. (1977): Malnutritian and the immune response In: Kroc foundation Series, Vol. 7, New York, USA, Raven Press, PP 468.
Bongiorni-Malave, I.B. and Pocino, M. (1980) : Abnormal regulatory control of the antibody response to hetrologous erythrocytes in protein-calorie-malnourished mice, Clin. Immunol. Immunopathol., Vol. 16 No. 1 , pp. 19-29.
Malave, I., Nemeth, A. and Pocino, M., (1980) : changes in lymphocyte populations in proteins-caloriedefieient mice, Cellular, Vol. 49, No. 2, pp. 235-249.
Gershwin, M. E., Keen, C. L., Fletcher, M. P. and Hurley, L. S. (1988): Trace element deficiencies and immune responsiveness. In : Trace elements in man and animals, Edited by Hurley, L. S, Keen, C. L. Lonnerdal, Bo, and Rucker, R. B, Plenuum press, New York and London, pp. 85-89.
Rigas, D. A., Rigas, E. C. and Head, C., (1979) : Biophasic toxicity of diethyldithiocarbamate, a metal chelator, to T leymphocytes and polymorphonucuclear granulocytes : Reversal by zinc and copper Biochem. Biophys. Res. Commun. Vol. 88, No. 2, pp. 373-379.
Walten, W. S. and Richard, N. P. Jr. (2003) : Elements metabolism and body composition, Mol. Nucl. Med. in press, pp. 253-300.
Malcolm, J. J., David, A. J. and Richard, H. T. E. (1985) : Measurements of calcium and other elements in muscle biopsy samples from patients with Duchenne muscular dystrophy, Vol. 147, No. 3, pp. 215-221.
Allen, D. G., Gervasio, O. L., Yeung, E. W. and Wheitehead, M. P. (2010) : Calcium and the damage pathways in muscular dystrophy. Can. J. Pysoiol. Pharmacol., Vol. 88, No. 2, pp. 83-91.
Imbert, N., Cognard, C., Duport, G., Guillou, C. and Raymand, G. (1995) : Abnormal calcium homeostasis in Duchenne muscular dystrophy myotubes contracting in vitro, Cell. Calcium, Vol. 18, No. 3, pp. 177-86.
Rena, Y. and Yael, H. (1978) : Elements in muscle measured and in vitro with X-ray spectrometry. Muscle and Nerve., Vol. 1, No. 6, pp. 486-494.
Caroline, A. M., Raphael, G., Rena, Y. and Victor, D. (1980) : Elements analysis of skeletal muscle in Duchenne muscular dystrophy using X-ray fluorescence spectrometry, Muscle & Nerve, Vol. 3, No. 6, pp. 502-508.
Hisao, K., Mieko, K. and Yashinori, I. (1991) : Manganese, Copper, Zinc and Iron concentrations and subcellulor distribution in two types of skeletal muscle., Exp. Biol. Med., Vol. 196, No. 1, pp. 83-88.
Turner, P. R., Fong, P. Y., Denetclaw, W. F. and Steinhardt, R. A. (1991) : Increased calcium influx in dystrophic muscle. JCB, Vol. 115, No. 6, pp. 1701-1712.
Arthur, J. R. and Duthie, G. G. (1994) : Free radicals and trace elements in muscle disorders and sporis, In : Trace elements and free radicals in oxidative disease, edited by Favier, A. E., Neve, J. and Faure, P. AOCS Press, U. K., pp. 241-248.
Baharch, M., Jay, R. M. and Mark, A. T. (2005) : Nutritional inadequacy in adults with muscular dystrophy, Muscle & Nerve, Vol. 31, No. 6, pp. 713-718.
Kando, H., Miura, M., Nakagaki, I., Sasaki, S., and Itokawa, Y. (1992) : Trace element movement and oxidative stress in skeletal muscle atrophied by immobilization, Am. Physiol. Soc. Vol. 262, No. 5 pt 1, pp. E583-90..
Gage, V. H., Drori, J. B., Franklin, D. and Schwartz, (1970) : Hypokalemic myopathy and elevation of serum enzymes, Arch. Neurol., Vol. 22, No. 4, pp. 335-341.
Howard, M. K., William, D. S., and Robert, N. R. (1983) : Malignant hyperthermia in a child with Duchenne muscular dystrophy, Pediatrics, Vol. 71, No. 1, pp. 118-119.
William, B., Benedict, C. and Muriance, L. (1963) : Body Potassium content in patients with muscular dystrophy, Anals. N. Y. Acad. Sci., Vol. 110, pp. 282-290.
Kassmann, R. J., Dorothy, C., Peterson, B. S., and Howard, L. A. (1965) : Studies in neuromuscular disease, Neurology, Vol. 15, No.9, pp. 855.
Hull, K. L. and Roses, A. D. (1976) : Stoichiometry of sodium and potassium transport in erythrocytes from patients with mytonic muscular dystrophy. J. Physiol., Vol. 254, pp. 169-181.
Edmonds, C. J., Smith, T., Griffiths, R. D., Mackenzie, J. and Ed. Wards, R. H. (1985) : Total body potassium and water, and exchangeable sodium in muscular dystrophy. Clinical. Science, London. Vol. 68, No. 4, pp. 379-85.
William, H. B., Marianne, L. and Benedict, C. (1967) : The significance of decreased body potassium concentrations in patients with muscular dystrophy and non dystrophic relatives, New. Engl. J. Med., Vol. 276, pp. 1349-1352.
Rowland, L. P., Layzar, R. S. and Kagen, L. J. (1968) : Lack of some muscle proteins in serum of patients with Duchenne dystrophy. Arch. Neurol, Vol. 18, No. 3, pp. 272-276.
Hopf, F. W., Turner, P. R. and Steinhardt, R. A. (2007) : Calcium misregulation and the pathogenesis of muscular dystrophy, Sub Cel. Biochem., Vol. 45, pp. 429-464.
Neve, J. (2005 ) : Selenium : An essential micronutrient with extended biological potency at supra-nutritional intakes , Trace elements in medicine Vol.6,No. 2, pp. 15-20.
Westermarck, T. and Atroshi, F. (2005) : Dietary approaches to patients with Duchenne muscular dystrophy (DMD), patients with spielmeyer-sergen disease, and patients with epilepsy, Trace elements in medicine, Vol. 6, No. 2, pp.27-32.
Alain, L., Mathieu, R., Alain, K., Pascale, G. and Valérie, A (2009) : Selenoprotein function and muscle disease, Biochemica. Et Biophysica Acta, Vol. 1790, No. 11, pp. 1569-1574.
Zunkley, H. (1988) : Clinical aspects of selenium metabolism, Biol. Trace. Elem. Res. Vol. 15, No. 1, pp. 139-146.
Harris, L. S., Robert, L. F., and James, N. E. (1962) : Magnesium and calcium in human muscular dystrophy, Am. J. Dis. Child, Vol. 103, No. 6, pp. 771-776.
Samuel, W. B., Erik, J. O. Dorothy, F. and Edwin, R. H. (1965) : Plasma and erythrocyte magnesium in muscular dystrophy, Am. J. Dis. Child, Vol. 110, No. 2, pp. 172-175.
Tulio, E. B., Syamal, K. B., Genaro, M. A. P., Caroly, M. C., David, P. and Barbara, B. (1982) : Muscle calcium and magnesium content in Duchenne muscular dystrophy. Neurology, Vol. 32, No. 10, pp. 1088-1092.
Csenkér, E., Diöszeghy, P., Fekete, I., and Mechler, F. (1982) : Ion concentrations in serum and cerebrospinal fluid of patients with neuromuscular diseases, Arch. Psychiatry, Mervenkr, Vol. 231, No. 3, pp. 251-8.
Carlier, L., Legrand, M., Riviére, H. and Navarro, J. (1993) : Nutritional assessment in Duchenne muscular dystrophy, Dev. Med. Child. Neurol., Vol. 35, No. 12, pp. 1074-1082147.
Walsh, A.,(1956):The application of atomic absorption spectra to chemical analysis, Spectrochim. Acta Vol. 7, pp. 108.
Skoog, D. A., Holler, F. J. and Nieman, T. A. (1998) : Prinicples of instrumental analysis, 5th Edition. Harcourt Brace & Company, Philadelphia. pp. 849.
John, H., Maxwell, J.D., Stewart, D.A., Parsons, V.,
Williams, R., (1971) : Altered calcium metabolism in epileptic children on anti-convulsants, British Medical Journal, Vol. 4, pp. 202-204.
Prasad, R., Singh, A., Das, B. K., Upadhyay, R. S., Singh, T. B., Mishra, O. P. (2009) : Cerebrospinal fluid and serum zinc copper, magnesium and calcium levels in children with idiopathic seizure, Journal of Clinical and Diagnostic Research, Vol. 3, No. 6, pp. 1841-1846.
. Lech, T. (2001) : Calcium and magnesium content in hair as a predictor of disease in children, Trace Elements and Electrolytes, Vol. 18 , No. 3, pp. 112-121.
. Avci, H., Kizilkan, N., and Yaman, M., (2008) : Comparison of trace elements concentrations in scalp hair of epileptic and normal subjects, Trace Elements and Electrolytes, Vol. 25 , No. 3 , pp. 147-155.
Barlow, P.J., Francois, P.E., Goldberg, I.J. Richardson, I., Izmeth, M.G., Kumpeson, K., and Sykes, P., (1986) : Trace metal abnormalities in long stay hyperactive mentally handicapped children and agitates senile dements, J Royal Soc Medicine. Vol. 79, No. 10, pp. 581-583.
Khanna, R. S., Kumar, R., Asthana, R. K., Negi, R., Pande, D., Kumar, A. and Khanna, H. D. (2009) : Role of trace element and antioxidants in free radical mediated injury in neonates, MASAUM Journal of Basic and Applied Science, Vol. 1, No. 3, pp. 543-547.
Adnan, M., Ahmed, G., Khaled, O., Indress, A. M., Ahmed, A., Hiatham, T., Wall, H. (2010) : Simultaneous Determination of Cd, Pd, Cu Zn and Se. In Human blood of Jordanian smokers, by ICP-OES, Biological Trace Element Research, Vol. 133, No. 1, pp. 1-11.
Guidotti, T. L., McNamra, J., Moses, M. S., (2008) : The interpretation of trace element analysis in body fluids, Indian Journal of Med. Res., Vol. 128, pp. 524-532.
Deniz, T., Ali, H. T., Saraymen, R (2008) : The effects of antiepileptic drugs on serum and hair trace element levels, Ankara. Universitesi Tip. Fakultesi. Mecmuasi, Vol. 61, No.2, pp. 73-76.
Soylak, M., Saracoglu, S., Divrikli, U., and Elci, L., (2001) : Copper and zinc concentrations of serum samples of healthy people living in Tokat, Turkey, Trace Element and Electrolytes, Vol. 18, No.1, pp. 47-40.
Delves H. T., Clayton, B. E., and Bicknel, J., (1973) : Concentration of trace metals in the blood of children, Br. J. Prev .Soc. Med., Vol. 27, pp. 100-107.
Kumar, S., Bajaj, M., Jain, D.C. and Yadav, H. S. (1988) : A search for the trace elemental deficiencies in grand mal epilepsy using atomic absorption spectrophotometric technique and catalytic agent in the cellular enzyme reaction, Proc. World .Congress on Clinical. Nutrition, Vol. 1, pp. 115A-121A.
Smith, W. G., and Bone, I., (1982) : Copper, zinc and magnesium plasma levels in epilepsy, J Neurol Neur Surg Psychiatry, Vol. 45, No. 11 , pp. 1072- 1073.
Kaji, M., Ito, N., Okuno, T., Momoi, T., Sasaki, H., Yamanake, C., Yorifuji, T., and Mikawa, H. (1992) : Serum copper and zinc levels in epileptic children with valporate treatment, Epilepsia, Vol. 33, No. 3, pp. 555-557.
Kumar, S., Kumar, V., and Jain, D. C. and Mittal . R. (2013): Trace element analysis in epileptic children. Open.J . Appl .Sci , Vol. 3, No.3, pp. 449-476.
