Trace Elemental Analysis and Some Mathematical Tools used to Study Migraine with the Help of Flame Atomic Absorption Spectroscopic Technique


  • Sanjeev Kumar Mittal Department of Physics, Medical Physics Research Laboratory, D.A.V. (P.G.) College, Muzaffar Nagar, India
  • Reena Mittal Department of Mathematics, Shri K. K. Jain College, Khatauli, India



Flame atomic absorption spectroscopy, trace elements, Migraine, Control, healthy



(1) Allen. C.M.C and Lueck,C.J.(2002): Neurological disease ,In :Davidson’s

Principles and Practice of Medicine ,Edited by Christopher, H., Edwin, R.C., Nicholas ,A.B. and Nicki , R.C., Churchill Livingstone ,Edinburgh, London, New York ,Oxford ,Philadelphia ,St Lous, Sydney Toronto , pp.1103-1117.

(2) May, A.and Goadsby, P.J. (1999): The trigeminovascular system in humans: Pathophysiologicimplications for primary headache syndromesof the neural influences on the cerebral circulation.Journal of Cerebral Blood Flow and Metabolism, Vol..19, pp 115-127.

(3) Campbell, J.K. and Sakai F. (1993): Migraine: Diagnosisand differential diagnosis. In: The Headaches, Edited byOlesen, J, Tfelt-Hansen P, Welch, K.M.A. Raven Press, New York, pp 277-281.

(4) Edlow, J.A. and Caplan ,L.R. (2000): Avoiding pitfallsin the diagnosis of subarachnoid hemorrhage.New England, Journal of Medicine, Vol. 342,pp:29-36.

(5) Smetana, G.W. (2000): The Diagnostic value ofhistorical features in primary headache syndromes: A Comprehensive review, Archivesof Internal Medicine, Vol. 160, pp 2729-2737.

(6) Liveing, E. (1873): Phenomena of the Paroxysm:Natural Succession; Unilateral and BilateralCharacters; The Disorder of Sight; of TactileSensibility and Taste; of Faculty of Speech;Psychical Phenomena; Giddiness, and Disordersof the Muscular Sense; Headache;Nausea and Vomiting; Drowsiness; Termination In: On Megrim, Sick-headache, andSome Allied Disorders: a Contribution to ThePathology of Nerve-storms. London, J. and Churchill, A., pp 63-150.

(7) Sacks, O. (1995): Migraine aura and classical migraine.In: Migraine: Revised and Expanded. London: Picador, pp 51-98.

(8) Russell, M.B. and Olesen, J. A.(1996):A nosographicanalysis of the migraine aura in a general population, Brain, Vol. 119, pp 355-361.

(9) Russell, M.B., Rasmussen, B.K., Fenger, K. andOlesen, J. (1996):

Migraine without aura and migrainewith aura are distinct clinical entities: a studyof four hundred and eighty-four male andfemale migraineurs from the general population, Cephalalgia, Vol. 16, pp 239-245.

(10) Rasmussen, B.K. and Olesen, J.(1992): Migraine withaura and migraine Withoutaura: an epidemiological study, Cephalalgia,Vol. 12, pp 221-228.

(11) Olesen, J. (1993): Migraine with aura and itssubforms. In: The Headaches, Edited by Olesen, J.,Tfelt-Hansen, P., Welch, K.M.A , NewYork, Raven Press pp 263-275.

(12) Sacks, O. (1995): The structure of migraine. In:Migraine: Revised and Expanded, London: Picador, pp 31.

(13) Selby, G. (1983): Migraine and its variants. Sydney:Adis Health Science Press, Vol. 33, pp 357.

(14) Blau, J.N. (1991): Migraine postdromes: Symptomsafter attacks, Cephalalgia, Vol. 11, pp 229-231.

(15) Welch, K.M.A., D’Andrea G., Tepley, N.,Barkley, G. and Ramadan, N.M. (1990): The concept ofmigraine as a state of central neuronal hyperexcitability,Neurologic Clinics, Vol. 8, pp 817-828.

(16) Welch, K.M.A. (1998): Current opinion in headachepathogenesis: introduction and synthesis, Current Opinion in Neurology, Vol. 11,pp 193-197.

(17) Ferrari, M.D. (1998): Migraine, Lancet, Vol. 351, pp 1043-1051

(18) Welch, K.M.A. (1986): Migraine: A biobehavioral disorder, Cephalalgia, Vol. 6(Suppl 4), pp 103-110.

(19) Diener, H.C, and May, A. (1996): A Position emissiontomography studies in migraine attacks. In:Migraine: Pharmacology and Genetics, Edited bySandler, M., Ferrari, M.D. and Harnett, S., Chapman &Hall Publishers, London, pp 109-116.

(20) Weiller, C., May, A., Limmroth, V., Jüptner,M., Kaube, H., Vschauck, R., Coenen, H.H. and Dlener, H.C. (1995): Brain stem activation in spontaneous human migraine attacks, Nature Medicine,Vol. 1, pp 658-660.

(21) Sicuteri, F. (1976): Migraine, a central biochemical dysnociception, Headache, Vol. 16, pp 145-159.

(22) Lance, J.W. (1993): The pathophysiology of migraine.In: Wolff’s Headache and Other HeadPain, Edited by Dalesio, D.J. and Silberstein, S.D . 6th edition, Oxford University Press, Oxford, pp 59-95.

(23) Lance, J.W. and Goadsby, P.J. (1998): Migraine: Pathophysiology.In: Mechanisms and Managementof Headache, 6th edition, Edited by Butterworth-Heinemann, Oxford,pp 79-115.

(24) Aurora, S.K., Ahmad, B.K,Welch, K.M.A., Bhardhwaj, P.and Ramadan, N.M.(1998): Transcranial magnetic stimulation confirms hyperexcitability of occipital cortex in migraine, Neurology, Vol. 50, pp


(25) Wray, S.H.(1999): The occipital cortex as a migrainegenerator. In: Educational Program Syllabus of the American Academy of Neurology 51st Annual Meeting. Edited by Welch, K.M., The AmericanAcademy of Neurology, Toronto, Ontario, Canada, pp 47-50.

(26) Parent, A.(1998): Pons, In: Carpenter’s HumanNeuroanatomy. 9th edition, Williams & Wilkins, Baltimore, pp 469-526.

(27) Goadsby, P.J.(1997): Pathophysiology of migraine: a disease of the brain. In: Headache. Edited by Goadsby, P.J and Silberstein, S.D. Butterwoth-Heineman, Boston: pp 5-24.

(28) Leao, A.A.P.(1994): Spreading depression of activity in cerebral cortex, Journal of Neurophysiology, Vol. 7, pp 379-390.

(29) Leao, A.A.P. and Morrison, R.S. (1945): Propagation of spreading

cortical depression, Journal of Neurophysiology, Vol. 8, pp 33-45.

(30) Lauritzen, M., Olsen, T.S., Lassen, N.A., Paulson, O.B. (1983): The role of spreading depression in acute brain disorders, Annals of Neurology, Vol. 14, pp 569-572.

(31) Lashley, K. (1941): Patterns of cerebral integrationindicated by the scotomas of migraine,Archives of Neurology and Psychiatry, Vol. 46,pp 333-339.

(32) Milner, P.M.(1958): Note on a possible correspondencebetween scotomas of migraine and spreading depression of Leao,Electroencephalography and Clinical Neurophysiology, Vol. 10,pp 705--.

(33) Wray, S.H., Mijovic-Prelec, D. and Kosslyn, S.M. (1995): Visual processing in migraineurs, Brain, Vol. 118,pp 25-35.

(34) Moskowitz, M.A.(1984): The neurobiology ofvascular head pain,

Annals of Neurology, Vol. 16, pp 157-168.

(35) Olesen, J., Friberg, L., Skyhoj-Olsen, T., Iversen, H.K., Lassen, N.A., Andersen, A.R.and Karle ,A . (1990): Timing and topography of cerebral blood flow, aura and headache during migraine attacks,Annals of Neurology, Vol. 28, pp 791-798.

(36) Moskowitz, M.A, and Macfarlane, R.(1993): Neurovascularand molecular mechanisms in migraine headaches, Cerebrovascular and BrainMetabolism Reviews , Vol. 5, pp 159-177.

(37) Olesen, J., Larsen, B., Lauritzen, M. (1981): Focalhyperemia followed by spreading oligemia and impaired rCBF activation in classic migraine, Annals of Neurology, Vol. 9, pp 344-352.

(38) Woods, R.P, Iacaboni, M., Mazziotta, J.C. (1994)Brief report: bilateral spreading cerebralhypoperfusion during spontaneous migraine headaches, New England Journal of Medicine, Vol. 331, pp 1689-1692.

(39) Curtrer, F.M., Sorensen, A.G., Weisskoff, R.M., Ostergaard, L., Sanchez del, R.M., Lee, J.E. ,Rosen ,R.B.and Maskowitz,M.A. (1998): Perfusion-weighted imaging defectsduring spontaneous migrainous aura, Annals of Neurology, Vol. 43, pp 25-31.

(40) Welch, K.M.A. (1993): Migraine and stroke. In:The Headaches, Edited by Olesen, J., Tfelt-Hansen, P. andWelch, K.M,A., Raven Press New York, pp 427-436.

(41) Tietjen, G.E. (2000): The relationship of migraineand stroke, Neuroepidemiology, Vol. 19,pp 13-19.

(42) Moskowitz, M.A., Curtrer, F.M. (1993): Sumatriptan:a receptor-targeted treatment for migraine, Annual Review of Medicine, Vol. 44, pp 145-154.

(43) Goadsby, P.J., Edvinsson, L.and Ekman, R. (1990):Vasoactive peptide release in the extracerebralcirculation of humans during migraine headache, Annals of Neurology, Vol. 28, pp 183-187.

(44) Goadsby, P.J. and Edvinsson, L. (1993): The trigeminovascular system and migraine: Studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats, Annals of Neurology, Vol. 33, pp 48-56.

(45) Edvinsson, L. and Goadsby, P.J. (1998): Neuropeptides in headache, European Journal of Neurology, Vol. 5, pp 329-341.

(46) Sacks, O. (1995): The physiological organisation of migraines, In: Migraine: Revised andExpanded, London: Picador, pp 193-204.

(47) Havanka-Kanniainen, H. (1986): Autonomic dysfunction in migraine with special reference to cardiovascular reflexes, plasma noradrenalinelevels and effects of nimodipine [Doctoral dissertation]. Oulu: University of Oulu.

(48) Merikangas, K.R.(1996): Sources of genetic complexity of migraine, In: Migraine: Pharmacology and genetics, Edited by Sandler, M., Ferrari, M., and Harnett, S. London: Chapman & Hall, pp 254-281.

(49) Rasmussen, B.K. (1995): Epidemiology of headache, Cephalalgia, Vol. 15, pp 15-68.

(50) Headache Classification Committee of the International Headache Society(1998). Classification and diagnostic criteria for headache disorders,

cranial neuralgias and facial pain, Cephalalgia, Vol. 8(Suppl 7), pp 1-96.

(51) Vahlqvist, B. (1955): Migraine in children, InternationalArchives of Allergy, Vol. 7, pp 348-355.

(52) Ad Hoc Committee on classification of headache. (1962): Classification on headache, Archives of Neurology, Vol. 6, pp 173-176.

(53) Waters, W.E. and O’Connor, P.J. (1971): Epidemiologyof headache and migraine in women, J. Neurosurg Psychiatry, Vol. 34, pp 148-153.

(54) Russell, M.B., Hidden, J., Sorensen, S.A. and Olesen, J. (1993): Familial occurrence of migraine without aura and migraine with aura, Neurology,Vol. 43,pp 1369-1373.

(55) Haan, J., Terwindt, G.M., Ferrari, M.D. (1997): Geneticsof migraine, Neurologic Clinics, Vol. 15, pp 43-60.

(56) Davies, N.P.and Hann, M.G. (1999): Neurological channelopathies:

diagnosis and therapy in the new millennium, Annals of Medicine, Vol. 31, pp 406-420.

(57) Sacks, O. (1993): Migraine: Revised and Expanded.London: Pan Books Limited, pp 338.

(58) Merikangas, K.R.(1996): Sources of genetic complexity of migraine. In: Migraine: Pharmacology and genetics, Edited by Sandler, M., Ferrari, M.and Harnett, S., London, Chapman & Hall, pp 254-281.

(59) Merikangas, K.R., Rich, N.J., Merikangas, J.R, Weissman, M.M., Kidd, K.K. (1988): Migraine and depression: association and familial transmission, Journal of Psychiatric Research, Vol. 22, pp 119-129.

(60) Barbara, L.N. and Vijay, M.T. (2015): Migraine and Epilesy: Review of the literature, Headache, Vol. 55, No 3, pp 359-380.

(61) Sullivan-Mee, M. And Bowman, B. (19970: Migraine related visual

field loss with prolonged recovery, Journal of the American optometric Association, Vol. 68, No 6, pp 377-88.

(62) Hemert, V.S, Breedveld, A.C., Rovers, J.M.P, Vermeidan, J.P.W., Witteman, B.J.M., Smiths, M., Roos, (2014): Migraine associated with gastrointestinal disorders: Review of the literature and clinical implications. Frontiers in Neurology, Vol. 5, pp 241-247.

(63) Nacey, T.A. (2007): Migraine and risk of stroke in young women, The internet Journal of Allied, Health sciences and practice, Vol. 5, No 3, Article 4.

(64) Goodsby, P.J., Zagmi, A.S. and Lambert, G.A.(1991): Neural processing of craniovascular pain: a synthesis of the central structures inVol.ved in migraine, Headache, Vol. 31, pp 365-371.

(65) Weiller, C., May, A., Limmorth, V., Juptner, M., Kaube, H., Schayack,R.V.,Coenen, H.H. and Diener, H.C. (1995): Brain stem activation in spontaneous migraine attacks, Nat.Med., Vol. 1, pp 658-660

(66) Olesen,J , Burstein,R , Ashina,M. and Tfelt-Hansen, P.(2009): Origin of pain in migraine : evidence for peripheral sensitization, The Lancet Neurology,Vol.8,No.7,pp.679-690.

(67) Mueller, L.L. (2007): Diagnosing and managing migraine headache, J.Am.Osteopath. Assoc. Vol. 107, No 10 suppl, pp. ES 10-6.

(68) Bernner, M., Oakley, C, and Lewis, D.W. (2007): Unusual headache

syndromes in children, Curr. Pain. Headache. Rep. Vol. 11, No 5, pp 383-389.

(69) Annequin, D. and Tourniaire, B. (2005): Migraine and headache in children, Arch. Pediator, Vol. 12, No 5, pp 624-629.

(70) Friedman, B.W. and Lipton, R.B. (2011): Headache in the emergency department, Current Paid Headache, Rep, Vol. 15, pp 1-14.

(71) Dooma, O. and Dumma, M.M. (2002): Association of Headaches and the metals, Biological Trace. Elem. Rev., Vol. 15, pp 1-14.

(72) Rao, A.M. (2005): Trace Element Estimation Method &Clinical Context, Ojhas,Published quaeterly Mangalore, South India, Vol. 4, No , pp 1-9.

(73) McCall, J.T., Goldstein, N.P, Smith, L.H. (1971): Implication of the trace metals in human diseases, Fed. Thoc., Vol. 30, pp

(74) Trace Minerals & Help for Migraines copyright © 2012 by Living Whole Foods. Inc.

(75) Pizza, V., Mainenti, M., Iannuzzi, S., Agresta, A., Cassano, D., Colucci d`Amato, C. And Capasso, A. (2013): Food Intolerance in Migraine, Archives, Vol. 1, pp 18-24.(

(76) Alan, Z., Coombes, N., Waring, R.H, Willians,A.S, Steventon, G.B. (1998): Plasma levels of neuroexcitatory amino acids in patients with migraine or tension headache, J.Neurol.Sci, Vol. 156,No 1, pp 102-106.

(77) Leira, R. and Rodriguez, R. (1996): Diet and migraine, Rev. Neurol, Vol. 24, No 129, pp 534-538.

(78) D`Eufermia, P., Finocchirao, R., Lendvai, D., Cell, M., Viozzl, L., Troiani, P., Turi, E., and Giardini, O. (1997): Eyrthroeyte and plasma level of Glutamate and Aspartate in children attected by migraine.

Cephalgia, Vol. 17, No 6, pp 652-657.

(79) Harrington, M.G., Fonteh, A.N., Cowan, R.P, Perrine, K., Pogoda, J.M., Biringer, R.G. and Hühmer, A.F. (2006): Cerebrospinal fluid sodium Increases in migraine, Headache, Vol. 46, No 7, pp 1128-1135.

(80) Üerol, E., Ulvi, H., Ihan, N., GÜlee, M., Ilhan, A. and Akyl, Ö. (2003): Determination of Copper, Zinc and Manganese in nail and serum from patients with migraine, Trace elements and electrolytes, Vol. 20, No 4, pp 230-233.

(81) Analytical Research Laboratory, Inc. Copyright 1991:Nutritional causes of headaches, pp:1-5.

(82) Morno, J., Carinic, C. and Brostoff, J. (1984): Migraine is a food allergic disease, Lancet, Vol. 2, No 8405, pp 719-21.

(83) Perkin, J.E. and Hartje, J. (1983): Diet and Migraine: A review

lecture, Journal of the American dietetic Association, Vol. 83, No 4, pp 459-463.

(84) Marcus, D.A. (2008): Managing headache during pregnancy and lactation, Expert, Rev. Neurother, Vol. 8, No 3, pp 385-395.

(85) Benert, A., Uduman, S.A., Quassimi, E.M, Khalaliy, G., Sztriha, L., Kilpelainen, H. and Obineche, E. (2000): Genetic and environmental factors associated with migraine in school children, Headache, Vol. 40, No 2, pp 152-157.

(86) Miziara, L., Bigal, M.E., Bordini, C.A and Speciali, J.G. (2003): Menstrual headache: semiolegical study in 100 cases. Arq, Neuropsiquiatr, Vol. 61, No 3A, pp 596-600.

(87) Hayriye, G., Edip, G., Sev degul, K., Mehmet, A., Orthan, K. and Asdurrahman, A. (2015): The levels of trace elements and heavy metals in patients with acute migraine headache, Journal of Pakistan. Medical Assocation, Vol. 65, pp 694-697.

(88) Walsh, A., (1956): The application of atomic absorption spectra to chemical analysis, Spectrochim. Acta. Vol.7, pp. 108.

(89) Skoog, D.A., Holler, F.J. and Nieman, T.A. (1998): Prinicples of instrumental analysis, 5th Edition. ; Harcourt Brace & Company , Philadelphia .pp 849.

(90) Gupta.S.C. and Kapoor,V.K. (2013):Multiple and partial Correaltion, In :Fundamental of Mathematical Statistics ,Eleventh Edition, Educational Publishers, Sultan Chand & Sons,Dariya Ganj,New Delhi.

(91) John, H., Maxwell, J.D., Stewart, D.A., Parsons, V., Williams, R. (1971): Altered calcium metabolism in epileptic children on anti-convulsants, British Medical Journal, Vol. 4, pp. 202-204.

(92) Prasad, R., Singh, A., Das, B. K., Upadhyay, R. S., Singh, T. B., Mishra, O. P. (2009): Cerebrospinal fluid and serum zinc copper, magnesium and calcium levels in children with idiopathic seizure, Journal of Clinical and Diagnostic Research, Vol.3, No. 6, pp. 1841-1846.

(93) Lech, T., (2001):Calcium and magnesium content in hair as a predictor of disease in children, Trace Elements and Electrolytes, Vol.18 , No. 3, pp. 112-121.

(94) Avci, H., Kizilkan, N., and Yaman, M. (2008): Comparison of trace elements concentrations in scalp hair of epileptic and normal subjects, Trace Elements and Electrolytes, Vol.25 , No. 3 , pp. 147-155.

(95) Barlow, P.J., Francois, P.E., Goldberg, I.J. Richardson, I., Izmeth, M.G., Kumpeson, K., and Sykes, P. (1986): Trace metal abnormalities in long stay hyperactive mentally handicapped children and agitates senile dements, J Royal Soc Medicine. Vol.79, No. 10, pp. 581-583.

(96) Khanna, R. S., Kumar, R., Asthana, R. K., Negi, R., Pande, D., Kumar, A. and Khanna, H. D. (2009):Role of trace element and antioxidants in free radical mediated injury in neonates, MASAUM Journal of Basic and Applied Science, Vol.1, No. 3, pp. 543-547.

(97) Adnan, M., Ahmed, G., Khaled, O., Indress, A. M., Ahmed, A., Hiatham, T., Wall, H. (2010) : Simultaneous Determination of Cd, Pd, Cu Zn and Se. In Human blood of Jordanian smokers, by ICP-OES, Biological Trace Element Research, Vol.133 , No. 1, pp. 1-11.

(98) Guidotti, T. L., McNamra, J., Moses, M. S. (2008):The interpretation of trace element analysis in body fluids, Indian Journal of Med. Res., Vol.128, pp. 524-532.

(99) Deniz, T., Ali, H. T., Saraymen, R. (2008): The effects of antiepileptic drugs on serum and hair trace element levels, Ankara .Universitesi Tip. Fakultesi. Mecmuasi, Vol.61, No.2 , pp. 73-76.

(100) Soylak, M., Saracoglu, S., Divrikli, U., and Elci, L. (2001):Copper and zinc concentrations of serum samples of healthy people living in Tokat, Turkey , Trace Element and Electrolytes, Vol. 18, No.1, pp. 47-40.

(101) Delves H. T., Clayton, B. E., and Bicknel, J. (1973) : Concentration of trace metals in the blood of children, Br. J. Prev .Soc. Med., Vol.27, pp. 100-107.

(102) Kumar, S., Bajaj, M., Jain, D.C. and Yadav, H. S. (1988) : A search for the trace elemental deficiencies in grand mal epilepsy using atomic absorption spectrophotometric technique and catalytic agent in the cellular enzyme reaction, Proc. World .Congress on Clinical. Nutrition, Vol.1, pp. 115A-121A.

(103) Smith, W. G., and Bone, I. (1982): Copper, zinc and magnesium plasma levels in epilepsy, J Neurol Neur Surg Psychiatry, Vol.45 ,No. 11 , pp. 1072- 1073.

(104) Kaji, M., Ito, N., Okuno, T., Momoi, T., Sasaki, H., Yamanake, C., Yorifuji, T., and Mikawa, H. (1992) : Serum copper and zinc levels in epileptic children with valporate treatment, Epilepsia, Vol. 33, No. 3, pp. 555-557.

(105) Kumar, S., Kumar, V., and Jain, D. C. and Mittal . R. (2013): Trace element analysis in epileptic children. Open.J . Appl .Sci , Vol.3,No., pp.449-476.

(106) Kumar, S., Mittal . R. Chaudhary, S and Jain, D. C. (2014): Role of trace elements inAlzheimer’s disease ,Open. Access.Library, Vol.1,No. e714,, pp.1-30.

(107) Kumar, S, Mittal,R., Sweety and Jain, D. C. (2014): Role of trace elements in Duchenne Muscular Dystrophy, Journal .of Biomedical . Engineering .Med .Imaging, Vol.1,No.5, pp.71-121.




How to Cite

Kumar Mittal, S., & Mittal, R. (2016). Trace Elemental Analysis and Some Mathematical Tools used to Study Migraine with the Help of Flame Atomic Absorption Spectroscopic Technique. Journal of Biomedical Engineering and Medical Imaging, 3(4), 30.