Radio Frequency Ablation of Liver Tumor-Influence of Vein Wall and Location of Large Vessels


  • MD Mohaiminul Islam Bangladesh University of Engineering and Technology, Bangladesh;
  • Muhammad Asadul Islam Bangladesh University of Engineering and Technology, Bangladesh;



RFA, Vein, blood vessel, electrode


Radiofrequency ablation (RFA) is a process that uses RF energy which is one form of electromagnetic energy to destroy cancer cells. This is a minimally invasive technique to treat some kinds of cancer and can be applied to nonsurgical patients. The frequency range of RF current is between 300 kHz to 1 MHz. Tumors from lung, liver, kidney and bone may be removed by performing RFA. Here in our model a patient specific simulator for Radiofrequency ablation (RFA) of liver tumors has been developed and the effects of the presence of blood vessel inside the liver tissue on the temperature distribution and the volume of ablation has been shown. And the effect of temperature distribution on the distance between large blood vessel and electrode tip has been shown, all these effects has been shown for two different models one is with vein wall and one without vein wall. Heat is generated within liver tumors utilizing RF energy from RF current where the RF current is generated using a power generator. With the heat generation, the tissue temperature reaches a temperature where cell death occurs. This cell death occurs when the cells are heated to approximately 50 °C or above. Temperature should not exceed 100 °C because it will cause overheating. We develop the model using ANSYS 16.2 and numerically solve the problem to view the variation of temperature around the electrode tip within the liver tissue. We consider a model with blood flow inside a vessel and which is in the vicinity of the heated tissue and a model without a vessel.

Author Biography

MD Mohaiminul Islam, Bangladesh University of Engineering and Technology, Bangladesh;

Mechanical Engineer


(1) "Adult Primary Liver Cancer Treatment (PDQ®)–Patient Version". NCI. 6 July 2016. Retrieved 29 September 2016.

(2) World Cancer Report 2014. World Health Organization. 2014. pp. Chapter 5.6. ISBN 9283204298.

(3) GBD 2013 Mortality and Causes of Death, Collaborators (17 December 2014). "Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.". Lancet. 385: 117–71. doi:10.1016/S0140-6736(14)61682-2. PMC 4340604Freely accessible. PMID 25530442

(4) 4Tungjitkusolmun S, Tyler Staelin S, Haemmerich D, Tsai J-Z, Cao H, Webster J G, Lee F

T, Mahvi D M, Vorperian V R. Three-dimensional finite-element analyses for radiofrequency

hepatic tumour ablation. IEEE Trans Biomed Eng, vol. 49, No. 1,

(5) Solbiati L, Ierace T, Tonolini M, Osti V, Cova L. Radiofrequency thermal ablation of

hepatic metastases. European journal of ultrasound, vol. 13 149-158, 2001.

(6) Welp C, Siebers S, Werner E, Werner J. Invetsigation of the influence of blood flow rate

on large vessel cooling in hepatic radiofrequencey ablation.

Biomed Tech, vol. 51 337-346, 2006.

(7) Hammerich D, Wright A W, Mahvi D M, Lee Jr F T, Webster J G. Hepatic bipolar

radiofrequency ablation creates coagulation zones close to blood vessels: a finite element

study. Medical & biological engineering & computing, vol. 41, 317-323, 2003.

(8) Kolios M C, Sherar M D Hunt J W. Large blood vessel cooling in heated tissues: a

numerical study. Phys. Med. Biol., vol. 40 477-494, 1995.

(9) Gilliams A R, Liver ablation therapy, a review article. The British journal of radiology, vol. 77 713-723, 2004.

(10) Valleylab Cool-tipTM RF ablation system, product information. Available at:, accessed: 2007-12-20.

(11) surfed on May 2010

(12) Dos Santo I, Haemmerich D, da Silva Pinheiro C, Ferreira da Rocha A, Effect of variable heat transfer coefficient on tissue temperature next to a large vessel during radiofrequency tumor ablation, BioMedical Engineering OnLine, 7 -21, 2008.

(13) Wren J, On medical thermal treatment –modelling, simulationand experiments, Dissertations no. 763, Linköpings University, 2002.

(14) Duck F, Physical properties of tissue, Academic press,

London, U.K, 1990.

(15) Berjano E J. Theoretical modelling for radiofrequency ablation: state-of-the-art and challenges for the future. Biomedical engineering online, vol. 5:24, 2006.

(16) Wren J, On medical thermal treatment –modelling, simulationand experiments, Dissertations no. 763, Linköpings University, 2002.

(17) Haemmerich D, Laeseke P F. Thermal tumour abalation: devices, clinical applications and

future directions. International journal of hyperthermia, vol. 21:8 755-760, 2005.

(18) Latif M J, Heat Convection, Springer, Heidelberg, Germany, 2006.

(19) surfed on November 2010

(20) Miguel A. F., de O Nascimento F. A, da Rocha A. F, dos Santos I, An instrument to measure the convective heat transfer coefficient on large vessels. Conf. Proc. IEEE Eng Med Biol. Soc, 2008.

(21) P. Keangin, et al., An analysis of heat transfer in liver tissue during microwave ablation using single and double slot antenna, Int. Commun. Heat Mass Transf. (2011), doi:10.1016/j.icheatmasstransfer.2011.03.027

(22) Material property values used in the study obtained from Mordon et al. (2006) and Agalar et al. (2012) .

(23) Berjano EJ. Theoretical modeling for radiofrequencyablation: stateofthe-art and Challenges for the future. Biomed Eng Online. 2006. Apr 18;5:24.

(24) Ottosen N, Petersson H, Introduction to the finite element method, Prentice Hallinternational, UK, 1992.

(25) Montree Chaichanyut and Supan Tungjitkusolmun, Microwave Ablation Using Four-Tine Antenna: Effects of Blood Flow Velocity, Vessel Location, and Total

Displacement on Porous Hepatic Cancer Tissue,2016




How to Cite

Islam, M. M., & Asadul Islam, M. (2017). Radio Frequency Ablation of Liver Tumor-Influence of Vein Wall and Location of Large Vessels. British Journal of Healthcare and Medical Research, 4(6), 23.