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Coronavirus (Covid-19) is known to cause several health challenges such as common cold, breathing problem, severe acute respiratory syndrome and headache. Therefore, the study investigated outcome of health education intervention on the knowledge of management of coronavirus challenges in Ekiti state. The study employed pre-test, post-test quasi experimental research design. The target population was made up of residents of Ekiti State while the sample size was made up of 150 respondents purposively selected in the 3 senatorial districts of the State. The research Instrument was a self-designed questionnaire that consisted of three sections A, B and C. The research instrument was validated by experts in the field of nursing, health education and Tests & Measurement. The reliability of the research instrument was carried out through a pilot study and reliability co-efficient of 0.877 was obtained. Data collected were analyzed using descriptive and inferential statistics. The result revealed that Knowledge level of Coronavirus mean score at pre-test was 10.18 while after the intervention was 17.83. Knowledge of management of Coronavirus challenges mean score at pre-test was 8.21 while after the intervention was 17.31. It was also revealed that there were significant differences between the pre and post intervention knowledge level of Coronavirus (t = 24.74, p<0.05) and between the pre and post intervention knowledge of management of Coronavirus challenges (t = 40.34, p<0.05). It was recommended among others that Health educators, nurses and other medical officials should intensify effort in educating the populace about the management of Coronavirus.
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