Unusual case of childhood tuberculosis: Clinical report and literatura review.

Authors

  • Natalia Martínez Córdoba Child neurology resident, Universidad Militar Nueva Granada, Bogotá, Colombia
  • Pilar Guerrero Child neurologist, Hospital Militar Central, Bogotá, Colombia
  • Cámilo Sánchez Martín Child Neurologist, Bogotá, D.C
  • Andrea Rangel Child neurologist, Bucaramanga, Colombia
  • Marco Luciano Charry Radiologist, Hospital Militar Central, Bogotá Colombia ORCID

DOI:

https://doi.org/10.14738/bjhmr.101.14006

Keywords:

tuberculosis, tuberculoma, pediatrics, vasculitis, central nervous system.

Abstract

Introduction: Tuberculosis of the central Nervous system occurs more frequently in children under three years of age and in immunodeficient populations, in which it is usual that it manifests as a disseminated disease, the frequency is usually higher in countries with a high prevalence of tuberculosis, and its presentation is related to a period of rapid dissemination of the germ that can occur during the first year, with the first infection.  

Case: 3-year-old girl with a history of latent tuberculosis who presented acute symptoms of eyelid ptosis, impossibility to adduct, and pupillary hyperactivity, with neuroimaging findings of a lesion suggestive of tuberculous granuloma, as well as bilateral mesencephalic and thalamic vascular lesions, which allowed concluding a tuberculosis involvement of the CNS. He received antituberculosis treatment with tetra conjugate, achieving clinical stability.  

Conclusions: The case presented describes a rare presentation of childhood tuberculosis with the finding of tuberculoma without meningitis of unusual location in the subarachnoid space and vasculitis. The diagnosis and management of this pathology, as well as a correct adherence to treatment, will have an impact on the morbidity and mortality of the patients, considering the variable clinical spectrum. 

 

References

To U, Ferences E. Tuberculosis. NICE Guidel. 2016;(January).

Nelson LJ, Schneider E, Wells CD, Moore M. Epidemiology of childhood tuberculosis in the United States, 1993-2001: the need for continued vigilance. Pediatrics. 2004;114(2):333–41.

Kumar R, Dwivedi A, Kumar P, Kohli N. Tuberculous meningitis in BCG vaccinated and unvaccinated children. J Neurol Neurosurg Psychiatry. 2005;76(11):1550–4.

Farrar J, Newton C. Tuberculous meningitis. J Neurol Neurosurg Psychiatry. 2000;68(2):135–6.

Nicolls DJ, King M, Holland D, Bala J, Del Rio C. Intracranial tuberculomas developing while on therapy for pulmonary tuberculosis. Lancet Infect Dis. 2005;5(12):795–801.

Tabbara KF. Tuberculosis. Curr Opin Ophthalmol. 2007;191:569–76.

Thwaites G, Fisher M, Hemingway C, Scott G, Solomon T, Innes J. British Infection Society guidelines for the diagnosis and treatment of tuberculosis of the central nervous system in adults and children. J Infect. 2009;59(3):167–87.

Tuon FF, Higashino HR, Lopes MIBF, Litvoc MN, Atomiya AN, Antonangelo L, et al. Adenosine deaminase and tuberculous meningitisA systematic review with meta-analysis. Scand J Infect Dis. 2010;

Ayieko J, Abuogi L, Simchowitz B, Bukusi EA, Smith AH, Reingold A. Efficacy of isoniazid prophylactic therapy in prevention of tuberculosis in children: A meta-analysis. BMC Infect Dis. 2014;14(1).

Ramírez M, Cortés E, Betancur J, Garcés C. Tuberculosis cerebral sin meningitis en un niño inmunocompetente. Rev Chil infectología [Internet]. 2018;35(2):207–12. Available from: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-10182018000200207&lng=en&nrm=iso&tlng=en

Chaudhary V, Bano S, Garga UC. Central Nervous System Tuberculosis: An Imaging Perspective. Can Assoc Radiol J. 2017;68(2):161–70.

Sharma PK, Saikia B, Hussain Z, Kochar P. Isolated cerebellar tuberculoma. Pediatr Neurol [Internet]. 2013;49(4):296–7. Available from: http://dx.doi.org/10.1016/j.pediatrneurol.2013.05.018

Alemayehu T, Ergete W, Abebe W. Frontal Lobe Tuberculoma: A Clinical and Imaging Challenge. Ethiop J Health Sci. 2017;27(6):677–80.

Donald PR, Van Toorn R. Use of corticosteroids in tuberculous meningitis. Lancet. 2016;387(10038):2585–7.

Prasad K, Singh MB, Ryan H. Corticosteroids for managing tuberculous meningitis. Cochrane Database Syst Rev. 2016;2016(4).

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Published

2023-02-22

How to Cite

Martínez Córdoba, N., Pilar Guerrero, Cámilo Sánchez Martín, Andrea Rangel, & Marco Luciano Charry. (2023). Unusual case of childhood tuberculosis: Clinical report and literatura review . British Journal of Healthcare and Medical Research, 10(1), 185–193. https://doi.org/10.14738/bjhmr.101.14006