The Biorevitalization Effect of Serum Containing Rose Apple Leaf Extract on the Parameters of Premature Skin Aging

Authors

  • Gabriella Cynthia Department of Biomedical Sciences, Faculty of Medicine, Universitas Prima Indonesia, Medan, Indonesia
  • Edy Fachrial Laboratory of Molecular Biology, Faculty of Medicine, Universitas Prima Indonesia, Medan, Indonesia
  • I. Nyoman Ehrich Lister Department of Medical Sciences, Faculty of Medicine, Universitas Prima Indonesia, Medan, Indonesia

DOI:

https://doi.org/10.14738/jbemi.93.12570

Keywords:

syzygium jambos, premature aging, pore, melanin, sensitivity

Abstract

Rose apple (Syzygium jambos) is known for its antioxidants and could potentially be used as an anti-aging cosmetic. This study reported the potential of rose apple leaf extract as a skin serum for the biorevitalization- with improvement based on pigmentation, wrinkles, pore, and sensitivity parameters in the skin of women aged 30 to 40. The skin serum was formulated with various concentrations of 5%, 10%, and 15% of rose apple leaf extract. The Pretest-Posttest with Control Group Design were conducted by measuring skin condition with the API-100 Aram Huvis Innovation Skin Analysis System. Data analyses using the Kruskal-Wallis’s test and Mann-Whitney’s test. The phytochemical contents of rose apple leaf extracts showed alkaloids, flavonoids, saponins, phenol as gallic acid, and tannic acid, which function as antioxidants that is comparable to vitamin C with IC50 of up to 7.29%. Experimental data showed that rose apple leaf extract affects skin biorevitalization based on reduction in pore size, skin pigmentation, and sensitivity parameters. This study strongly suggests the potential of rose apple leaf extract as an anti-aging ingredient to prevent premature skin aging.

References

T. C. Flynn and W. P. Coleman, “Topical revitalization of body skin,” J. Eur. Acad. Dermatology Venereol., vol. 14, no. 4, 2000, doi: 10.1046/j.1468-3083.2000.00104.x.

S. González, M. Fernández-Lorente, and Y. Gilaberte-Calzada, “The latest on skin photoprotection,” Clin. Dermatol., vol. 26, no. 6, 2008, doi: 10.1016/j.clindermatol.2007.09.010.

A. Svobodová, J. Psotová, and D. Walterová, “Natural phenolics in the prevention of UV-induced skin damage. A review.,” Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia, vol. 147, no. 2. 2003, doi: 10.5507/bp.2003.019.

G. J. Fisher et al., “Mechanisms of photoaging and chronological skin aging,” Arch. Dermatol., vol. 138, no. 11, 2002, doi: 10.1001/archderm.138.11.1462.

M. Pawlaczyk, M. Lelonkiewicz, and M. Wieczorowski, “Age-dependent biomechanical properties of the skin,” Postepy Dermatologii i Alergologii, vol. 30, no. 5. 2013, doi: 10.5114/pdia.2013.38359.

M. Foldvari, “Non-invasive administration of drugs through the skin: Challenges in delivery system design,” Pharmaceutical Science and Technology Today, vol. 3, no. 12. 2000, doi: 10.1016/S1461-5347(00)00317-5.

R. Sharma, N. Kishore, A. Hussein, and N. Lall, “Antibacterial and anti-inflammatory effects of Syzygium jambos L. (Alston) and isolated compounds on acne vulgaris,” BMC Complement. Altern. Med., vol. 13, pp. 1–10, 2013, doi: 10.1186/1472-6882-13-292.

M. A. Ghareeb, T. Mohamed, A. M. Saad, L. A. G. Refahy, M. Sobeh, and M. Wink, “HPLC-DAD-ESI-MS/MS analysis of fruits from Firmiana simplex (L.) and evaluation of their antioxidant and antigenotoxic properties,” J. Pharm. Pharmacol., vol. 70, no. 1, 2018, doi: 10.1111/jphp.12843.

M. Sobeh et al., “Phenolic compounds from Syzygium jambos (Myrtaceae) exhibit distinct antioxidant and hepatoprotective activities in vivo,” J. Funct. Foods, vol. 41, no. December, pp. 223–231, 2018, doi: 10.1016/j.jff.2017.12.055.

C. D. Djipa, M. Delmée, and J. Quetin-Leclercq, “Antimicrobial activity of bark extracts of Syzygium jambos (L.) Alston (Myrtaceae),” J. Ethnopharmacol., vol. 71, no. 1–2, pp. 307–313, 2000, doi: 10.1016/S0378-8741(99)00186-5.

D. S. Putro, “Agar Awet Muda.” Trubus Agriwidya, Ungaran, 1998.

S. Murugan, P. U. Devi, N. K. Parameswari, and K. R. Mani, “Antimicrobial activity of Syzygium jambos against selected human pathogens,” Int. J. Pharm. Pharm. Sci., vol. 3, no. 2, 2011.

J. R. Kuiate, S. Mouokeu, H. K. Wabo, and P. Tane, “Antidermatophytic triterpenoids from Syzygium jambos (L.) Alston (Myrtaceae),” Phyther. Res., vol. 21, no. 2, 2007, doi: 10.1002/ptr.2039.

T. K. Lim, Edible Medicinal and Non-Medicinal Plants, vol. 10. Dordrecht: Springer Netherlands, 2016.

P. Kotler, “Philip Kotler: some of my adventures in marketing,” J. Hist. Res. Mark., 2017, doi: 10.1108/JHRM-11-2016-0027.

D. Mulyawan and N. Suriana, AZ Tentang Kosmetik. Jakarta: PT Elex Media Komputindo, 2013.

A. O. Barel, M. Paye, and H. I. Maibach, Handbook of cosmetic science and technology. 2009.

Kurniawati, A. Y. and E. D. Wijayanti, “Karakteristik Sediaan Serum Wajah dengan Variasi Konsentrasi Sari Rimpang Temu Giring (Curcuma heyneana) Terfermentasi Lactobacillus bulgaricus,” Akad. Farm. Putra Indones. Malang, pp. 1–11, 2018.

R. Winter, A Consumer’s Dictionary of Cosmetic Ingredients-Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics and Cosmeceuticals. 2009.

V. T. Yin, H. A. Merritt, M. Sniegowski, and B. Esmaeli, “Eyelid and ocular surface carcinoma: Diagnosis and management,” Clin. Dermatol., vol. 33, no. 2, 2015, doi: 10.1016/j.clindermatol.2014.10.008.

D. F. Sunarno, “Formulasi dan Uji Aktivitas Losion Skin Anti-Aging yang Mengandung Ekstrak Kulit Pisang Raja (Musa paradisiacal L.),” Universitas Sumatera Utara, 2018.

Y.-H. Liao, S.-Y. Chen, S.-Y. Chou, P.-H. Wang, M.-R. Tsai, and C.-K. Sun, “Determination of chronological aging parameters in epidermal keratinocytes by in vivo harmonic generation microscopy,” Biomed. Opt. Express, vol. 4, no. 1, 2013, doi: 10.1364/boe.4.000077.

Z. Sun, Q. Huang, and C. Feng, “Complete chloroplast genome sequence of the rose apple, Syzygium jambos (Myrtaceae),” Mitochondrial DNA Part B Resour., vol. 5, no. 3, 2020, doi: 10.1080/23802359.2020.1826000.

D. G. E. Prayoga, K. A. Nocianitri, and N. N. Puspawati, “Antioksidan Ekstrak Kasar Daun Pepe ( Gymnema Reticulatum Br .) Pada Berbagai Jenis Pelarut,” J. Ilmu dan Teknol. Pangan, vol. 8, no. 2, pp. 111–121, 2019.

E. S. Syamsul, O. Anugerah, and R. Supriningrum, “Penetapan Rendemen Ekstrak Daun Jambu Mawar (Syzygium Jambos L. Alston) berdasarkan Variasi Konsentrasi Etanol dengan Metode Maserasi,” J. Ris. Kefarmasian Indones., vol. 2, no. 3, 2020, doi: 10.33759/jrki.v2i3.98.

L. K. Chua, C. L. Lim, A. P. K. Ling, S. M. Chye, and R. Y. Koh, “Anticancer Potential of Syzygium Species: a Review,” Plant Foods for Human Nutrition, vol. 74, no. 1. 2019, doi: 10.1007/s11130-018-0704-z.

D. Ávila-Peña, N. Peña, L. Quintero, and H. Suárez-Roca, “Antinociceptive activity of Syzygium jambos leaves extract on rats,” J. Ethnopharmacol., vol. 112, no. 2, 2007, doi: 10.1016/j.jep.2007.03.027.

S. Athikomkulchai, V. Lipipun, T. Leelawittayanont, A. Khanboon, and N. Ruangrungsi, “Anti-Herpes Simplex Virus Activity of Syzygium jambos,” J. Heal. Res., vol. 22, no. 1, 2008.

L. Apaza Ticona, B. Souto Pérez, V. Martín Alejano, and K. Slowing, “Anti-inflammatory and Anti-arthritic Activities of Glycosylated Flavonoids from Syzygium jambos in Edematogenic Agent-Induced Paw Edema in Mice,” Rev. Bras. Farmacogn., vol. 31, no. 4, 2021, doi: 10.1007/s43450-021-00167-0.

M. A. Ochieng, W. Ben Bakrim, G. T. M. Bitchagno, M. F. Mahmoud, and M. Sobeh, “Syzygium jambos L. Alston: An Insight Into its Phytochemistry, Traditional Uses, and Pharmacological Properties,” Front. Pharmacol., vol. 13, no. January, 2022, doi: 10.3389/fphar.2022.786712.

L. K. Darusman, I. Batubara, T. Mitsunaga, M. Rahminiwati, E. Djauhari, and K. Yamauchi, “Tyrosinase kinetic inhibition of active compounds from intsia palembanica,” Res. J. Med. Plant, vol. 6, no. 8, 2012, doi: 10.3923/rjmp.2012.615.620.

H. Hossain, S. E. Rahman, P. N. Akbar, T. A. Khan, M. M. Rahman, and I. A. Jahan, “HPLC profiling, antioxidant and in vivo anti-inflammatory activity of the ethanol extract of Syzygium jambos available in Bangladesh,” BMC Res. Notes, vol. 9, no. 1, pp. 1–8, 2016, doi: 10.1186/s13104-016-2000-z.

W. Noé, S. Murhekar, A. White, C. Davis, and I. E. Cock, “Inhibition of the growth of human dermatophytic pathogens by selected australian and asian plants traditionally used to treat fungal infections,” J. Mycol. Med., vol. 29, no. 4, 2019, doi: 10.1016/j.mycmed.2019.05.003.

S. Alok, S. K. Jain, A. Verma, M. Kumar, A. Mahor, and M. Sabharwal, “Herbal antioxidant in clinical practice: A review,” Asian Pacific Journal of Tropical Biomedicine, vol. 4, no. 1. 2014, doi: 10.1016/S2221-1691(14)60213-6.

A. Santiago-Perez et al., “Syzygium Jambos: A Potential Therapeutic Approach to Treat the Vascular and Hematological Complications of Sickle Cell Disease,” Arterioscler. Thromb. Vasc. Biol., vol. 36, no. suppl_1, 2016, doi: 10.1161/atvb.36.suppl_1.345.

N. M. Schäfer, R. J. Balwierz, K. Jasiński, and U. Skotnicka-Graca, “A significance of botanical and synthetic ingredients in supporting skin depigmentation process,” Farm. Pol., vol. 77, no. 8, 2021, doi: 10.32383/FARMPOL/142651.

W. hastuty Harahap, “Formulasi Sediaan Krim Ekstrak Etanol Daun Nangka (Artocarpus heterophyllus Lam) Sebagai Anti-Aging,” J. Univ. Sumatra Utara, 2017.

. D. E. Mariati et al., “Robusta Extract Cream Ameliorated Ultraviolet B-induced Wrinkle Skin of Mice by the Regulation of Epidermal Thickness and Inhibition of MMP-1,” Indones. Biomed. J., vol. 13, no. 1, 2021, doi: 10.18585/inabj.v13i1.1428.

M. Chatatikun and A. Chiabchalard, “Thai plants with high antioxidant levels, free radical scavenging activity, anti-tyrosinase and anti-collagenase activity,” BMC Complement. Altern. Med., vol. 17, no. 1, p. 487, Dec. 2017, doi: 10.1186/s12906-017-1994-7.

V. Bergamante, G. C. Ceschel, S. Marazzita, C. Ronchi, and A. Fini, “Effect of vehicles on topical application of aloe vera and arnica montana components,” Drug Deliv., vol. 14, no. 7, 2007, doi: 10.1080/10717540701202960.

A. Abdul Karim et al., “Efficacy of cocoa pod extract as antiwrinkle gel on human skin surface,” J. Cosmet. Dermatol., vol. 15, no. 3, pp. 283–295, Sep. 2016, doi: 10.1111/jocd.12218.

Downloads

Published

2022-06-29

How to Cite

Cynthia, G., Fachrial, E., & Ehrich Lister, I. N. (2022). The Biorevitalization Effect of Serum Containing Rose Apple Leaf Extract on the Parameters of Premature Skin Aging. British Journal of Healthcare and Medical Research, 9(3), 228–248. https://doi.org/10.14738/jbemi.93.12570