TY - JOUR AU - Shahmirzadi, Danial AU - Lin, Kexin AU - Li, Han PY - 2016/09/14 Y2 - 2024/03/29 TI - Effects of the Medium-Wall Modulus Contrast on the Pulse Wave Imaging (PWI) of Aortic Phantoms JF - British Journal of Healthcare and Medical Research JA - BJHMR VL - 3 IS - 4 SE - Original Articles DO - 10.14738/jbemi.34.2101 UR - https://journals.scholarpublishing.org/index.php/JBEMi/article/view/2101 SP - 18 AB - Given its close correlation to cardiovascular pathologies, change in arterial stiffness has been deemed as a reliable biomarker for predicting cardiovascular events. The feasibility of using the ultrasound-based method of Pulse Wave Imaging (PWI) for estimating the arterial Pulse Wave Velocity (<em>PWV</em>) as surrogate of the wall stiffness has shown capacity for enhancing cardiovascular noninvasive diagnosis. The Moens-Korteweg equation, which is the baseline for the modulus-<em>PWV</em> relationship, does not account for factors such as the stiffness of the surroundings and the continuous pulsatile flow; while these factors are prevalent in phantom and <em>in vitro</em> PWI studies and could affects the <em>PWV </em>measurements. The objective of the present study is to quantify the correlation between the wave propagations and the stiffness of the surrounding medium, under various flow speeds. The <em>PWV</em> results were quantified in terms of their <em>r<sup>2</sup></em> and <em>SNR</em>, indicating the uniformity of the waves and variations in the measurements. The characteristic curves were developed in terms of the wall-to-medium modulus contrast that could be used as the reference for selecting the optimized gel and medium stiffness parameters that minimize the boundary conditions effects and maximize the <em>SNR</em> and r<sup>2</sup>. ER -