Respiratory Complex II and SCOT-Oxct1 Compete for succinyl-CoA in Ketolytic Dependent Tumours

Abstract

The present work recalls main features of tumour cell metabolism, explaining their ketolytic dependency and vulnerability; we explored the interface between the respiration chain complexes and the nutritional supply of succinyl-CoA to the ketolytic enzyme SCOT- Oxct1. We indicated several target points in ketolysis and fatty acid synthesis pathways that would affect tumour cells, rendered vulnerable by their ketolytic dependency.